4lmf
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4lmf| PDB=4lmf | SCENE= }} | {{STRUCTURE_4lmf| PDB=4lmf | SCENE= }} | ||
===C1s CUB1-EGF-CUB2=== | ===C1s CUB1-EGF-CUB2=== | ||
| + | {{ABSTRACT_PUBMED_23922389}} | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
[[4lmf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMF OCA]. | [[4lmf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LMF OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023922389</ref><references group="xtra"/><references/> | ||
[[Category: Complement subcomponent C1s]] | [[Category: Complement subcomponent C1s]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 05:03, 28 August 2013
Contents |
C1s CUB1-EGF-CUB2
Template:ABSTRACT PUBMED 23922389
Disease
[C1S_HUMAN] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Function
[C1S_HUMAN] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
About this Structure
4lmf is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Venkatraman Girija U, Gingras AR, Marshall JE, Panchal R, Sheikh MA, Gal P, Schwaeble WJ, Mitchell DA, Moody PC, Wallis R. Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13916-20. doi:, 10.1073/pnas.1311113110. Epub 2013 Aug 6. PMID:23922389 doi:10.1073/pnas.1311113110
