4lrg

From Proteopedia

proteopedia linkproteopedia link

Revision as of 21:20, 7 August 2013 (edit) OCA (Talk | contribs) ← Previous diff		Revision as of 06:33, 14 August 2013 (edit) (undo) OCA (Talk | contribs) Next diff →
Line 32:		Line 32:
	[[Category: Pardo, E.]]		[[Category: Pardo, E.]]
	[[Category: Poy, F.]]		[[Category: Poy, F.]]
		+	[[Category: Ravichandran, S.]]
	[[Category: Sandy, P.]]		[[Category: Sandy, P.]]
-	[[Category: Sankaranarayanan, R.]]
	[[Category: Sims, R.]]		[[Category: Sims, R.]]
	[[Category: Taylor, A.]]		[[Category: Taylor, A.]]

---

Revision as of 06:33, 14 August 2013

Template:STRUCTURE 4lrg

Contents 1 Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide 2 Disease 3 Function 4 About this Structure 5 Reference

Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.^{[1] [2]}

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4lrg is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0