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Thioesterase
From Proteopedia
| Line 25: | Line 25: | ||
[[1q4t]] - ArTE + 4-hydroxyphenyl CoA<br /> | [[1q4t]] - ArTE + 4-hydroxyphenyl CoA<br /> | ||
[[1q4u]] - ArTE + 4-hydroxybenzyl CoA<br /> | [[1q4u]] - ArTE + 4-hydroxybenzyl CoA<br /> | ||
| - | [[3r32]], [[3r35]], [[3r37]], [[3r38]], [[3r3c]], [[3r3d]], [[3r3f]], [[3tea]] - ArTE (mutant) + 4-hydroxyphenacyl CoA<br /> | + | [[3r32]], [[3r35]], [[3r37]], [[3r38]], [[3r3b]], [[3r3c]], [[3r3d]], [[3r3f]], [[3tea]] - ArTE (mutant) + 4-hydroxyphenacyl CoA<br /> |
| - | [[3r3a]] - ArTE (mutant) + 4-hydroxybenzoate<br /> | + | [[3r36]] - ArTE (mutant) + 4-hydroxybenzoate<br /> |
| + | [[3r3a]] - ArTE (mutant) + 4-hydroxybenzoate + CoA<br /> | ||
[[3r34]] - ArTE (mutant) + CoA<br /> | [[3r34]] - ArTE (mutant) + CoA<br /> | ||
| Line 61: | Line 62: | ||
'''Acyl-ACP TE''' | '''Acyl-ACP TE''' | ||
| - | [[2ess]] – TE – ''Bacterioides thetaiotaomicron'' | + | [[2ess]] – TE – ''Bacterioides thetaiotaomicron''<br /> |
| + | [[4gak]] – TE – ''Spirosoma linguale''<br /> | ||
| + | [[4gwh]] – TE – ''Yersinia pestis''<br /> | ||
| + | |||
| + | '''ACP-polyene TE''' | ||
| + | |||
| + | [[4i4j]] – TE – ''Streptomyces globisporus''<br /> | ||
'''Fluoroacetyl-CoA TE''' | '''Fluoroacetyl-CoA TE''' | ||
| Line 69: | Line 76: | ||
[[3kvu]] – ScTE + acetyl-CoA<br /> | [[3kvu]] – ScTE + acetyl-CoA<br /> | ||
[[3kvz]], [[3kw1]] – ScTE + FAcOPan<br /> | [[3kvz]], [[3kw1]] – ScTE + FAcOPan<br /> | ||
| - | [[3kx7]], [[ | + | [[3kx7]], [[3kx8]], [[3p2q]] – ScTE <br /> |
[[3p3f]] – ScTE (mutant) <br /> | [[3p3f]] – ScTE (mutant) <br /> | ||
[[3p3i]] - ScTE (mutant) + acetate derivative + CoA<br /> | [[3p3i]] - ScTE (mutant) + acetate derivative + CoA<br /> | ||
| + | |||
| + | '''DHNA-CoA TE''' | ||
| + | |||
| + | [[4k00]] – TE – ''Synechocystis''<br /> | ||
| + | [[4k02]] – TE – ''Arabidopsis thaliana''<br /> | ||
'''Ubiquitin TE''' | '''Ubiquitin TE''' | ||
| Line 167: | Line 179: | ||
[[3von]] – hUSP + E2 <BR /> | [[3von]] – hUSP + E2 <BR /> | ||
[[4ddg]], [[4ddi]] – hUSP + Ub<BR /> | [[4ddg]], [[4ddi]] – hUSP + Ub<BR /> | ||
| - | [[4ddi]] – hUSP (mutant) + Ub<BR /> | + | [[4ddi]], [[4i6l]] – hUSP (mutant) + Ub<BR /> |
[[4dhz]] – hUSP + E2 + Ub<BR /> | [[4dhz]] – hUSP + E2 + Ub<BR /> | ||
| + | [[4boq]] - hUSP OTU domain <BR /> | ||
| + | [[4boz]] - hUSP OTU domain (mutant) + Ub <BR /> | ||
| + | [[4bos]] - hUSP OTU domain (mutant) + Ub + OTUD2 peptide<BR /> | ||
| + | [[4fjv]] - hUSP OTUB2 + Ub <BR /> | ||
[[4dhj]] – nUSP + E2 + Ub - nematode<BR /> | [[4dhj]] – nUSP + E2 + Ub - nematode<BR /> | ||
[[4dhi]] – nUSP + E2 <BR /> | [[4dhi]] – nUSP + E2 <BR /> | ||
| + | [[2kzr]] – mUSP UBX-like domain – NMR<br /> | ||
| + | [[4kdi]], [[4kdl]] – yUSP UBX-like domain + transitional endoplasmic reticulum ATPase<br /> | ||
| + | [[3by4]], [[3c0r]] - yUSP OTU domain + Ub<BR /> | ||
[[3znh]] – USP + Ub – Crimean-Congo hemorrhagic fever virus<BR /> | [[3znh]] – USP + Ub – Crimean-Congo hemorrhagic fever virus<BR /> | ||
| Line 178: | Line 197: | ||
[[3qmv]], [[3qmw]] – TE –'' Streptomyces coelicolor'' | [[3qmv]], [[3qmw]] – TE –'' Streptomyces coelicolor'' | ||
| + | '''Orf6 TE''' | ||
| + | |||
| + | [[4i45]] – TE – ''Photobacterium profundum''<br /> | ||
| - | [[2av9 ]]– TE – ''Pseudomonas aeruginosa'' | + | [[2av9]], [[2o5u]], [[2o6b]], [[2o6t]], [[2o6u]], [[3qy3]] – TE – ''Pseudomonas aeruginosa'' |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:16, 18 May 2014
Thioesterase (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group. TEs are substrate-specific. Palmitoyl protein TE removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation. 4-hydroxybenzoyl-CoA TE converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA. Acyl-CoA TE hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism. Fluoroacetyl-CoA TE from Streptomyces cattleya hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate. Ubiquitin TE (USP) removes conjugated ubiquitin from proteins thus regulating protein level by preventing their degradation.
3D structures of thioesterase
Updated on 18-May-2014
Maristoyl-ACP-specific TE
1tht – TE – Vibrio harveyi
4-hydroxybenzoyl-CoA TE
1bvq – PsTE – Pseudomonas
1lo7 – PsTE + 4-hydroxyphenyl CoA
1lo9 - PsTE (mutant) + 4-hydroxybenzoyl CoA
1lo8 - PsTE + 4-hydroxybenzyl CoA
1q4s - ArTE + 4-hydroxybenzoate – 'Arthrobacter'
1q4t - ArTE + 4-hydroxyphenyl CoA
1q4u - ArTE + 4-hydroxybenzyl CoA
3r32, 3r35, 3r37, 3r38, 3r3b, 3r3c, 3r3d, 3r3f, 3tea - ArTE (mutant) + 4-hydroxyphenacyl CoA
3r36 - ArTE (mutant) + 4-hydroxybenzoate
3r3a - ArTE (mutant) + 4-hydroxybenzoate + CoA
3r34 - ArTE (mutant) + CoA
Palmitoyl protein TE
1eh5 – bTE1 + Palmitate – bovine
1ei9 – bTE1
1exw – bTE1 + hexadecylsulfonyl fluoride
1pja – hTEII – human
3gro - hTEI
Acyl-CoA TE
1c8u – EcTEII – Escherichia coli
1ivn – EcTEI
1jrl – EcTEI (mutant)
1j00 – EcTEI + diethyl phosphono derivative
1v2g, 1u8u - EcTEI + octanoic acid
2v1o – mTE7 hotdog domain – mouse
2q2b – mTE7 C terminal
3hlk – hTE2
3k2i – hTE4
2qq2 - hTE7 C terminal
3fo5 – hTE11 START domain
3b7k – hTE12
3rd7 – TE – Mycobacterium avium
3u0a – TEII – Mycobacterium marinum
1tbu – TE N terminal (peroximal) – yeast
Acyl protein TE
1fj2 – EcTEI
Acyl-ACP TE
2ess – TE – Bacterioides thetaiotaomicron
4gak – TE – Spirosoma linguale
4gwh – TE – Yersinia pestis
ACP-polyene TE
4i4j – TE – Streptomyces globisporus
Fluoroacetyl-CoA TE
3kuv, 3kuw, 3kvi – ScTE (mutant) + acetate derivative – Streptomyces cattleya
3kv7, 3kv8, 3p2r, 3p2s – ScTE + acetate derivative
3kvu – ScTE + acetyl-CoA
3kvz, 3kw1 – ScTE + FAcOPan
3kx7, 3kx8, 3p2q – ScTE
3p3f – ScTE (mutant)
3p3i - ScTE (mutant) + acetate derivative + CoA
DHNA-CoA TE
4k00 – TE – Synechocystis
4k02 – TE – Arabidopsis thaliana
Ubiquitin TE
USP 2
2zfy – hUSP – human
2hd5, 3nhe – hUSP + Ub
1tff – hUSP (mutant)
2ibi – hUSP (mutant) + Ub
USP 3
2qiy – USP + UBP-associated protein – yeast
USP 5
3ihp – hUSP + Ub
USP 7
2ylm, 2f1z – hUSP
2kvr – hUSP UBL domain - NMR
1nb8 – hUSP catalytic domain
1yze – hUSP N terminal domain
2f1w – hUSP TRAF-like domain
2f1x – hUSP TRAF-like domain + p53 peptide
2foj, 2foo – hUSP N terminal domain + p53 peptide
2f1y – hUSP TRAF-like domain + MDM2 peptide
2fop – hUSP N terminal domain + MDM2 peptide
1nbf – hUSP catalytic domain + ubiquitin aldehyde
1yy6 – hUSP N terminal domain + Epstein-Barr nuclear antigen
3mqr, 3mqs – hUSP + peptide
2xxn – hUSP + VIRF-4
4jjq – hUSP (mutant) + E2
USP 8
2a9u – hUSP N terminal domain
2gfo – hUSP catalytic domain
2gwf – hUSP rhodanese domain + ring finger protein
3mhh, 3m99, 4fip, 4fjc, 4fk5 – hUSP + SUS1 + SAGA-associated factors 11, 73
3mhs – hUSP + SUS1 + SAGA-associated factors 11, 73 + Ub
3n3k – hUSP + Ub inhibitor
USP 15
3lmn – hUSP DUSP domain
USP 16
2i50 – hUSP zinc finger domain - NMR
USP 21
3i3t – hUSP + Ub
3mtn – hUSP + Ub inhibitor
USP 28
2lva – hUSP N terminal - NMR
USP 33
2uzg – hUSP zinc finger domain - NMR
USP 37
3ihr – hUSP (mutant)
3a7s – hUSP catalytic domain (mutant)
USP Cyld
2vhf – hUSP
USP L1
3irt – hUSP (mutant)
2len – hUSP (mutant) - NMR
3ifw, 3kvf, 3kw5 – hUSP (mutant) + Ub
4dm9 – hUSP + peptide inhibitor
USP L5
3ris – hUSP catalytic domain
3rii – hUSP catalytic domain (mutant)
3tb3 – hUSP UCH domain (mutant)
USP ZranB1
3zrh – hUSP
USP OTUB1
3von – hUSP + E2
4ddg, 4ddi – hUSP + Ub
4ddi, 4i6l – hUSP (mutant) + Ub
4dhz – hUSP + E2 + Ub
4boq - hUSP OTU domain
4boz - hUSP OTU domain (mutant) + Ub
4bos - hUSP OTU domain (mutant) + Ub + OTUD2 peptide
4fjv - hUSP OTUB2 + Ub
4dhj – nUSP + E2 + Ub - nematode
4dhi – nUSP + E2
2kzr – mUSP UBX-like domain – NMR
4kdi, 4kdl – yUSP UBX-like domain + transitional endoplasmic reticulum ATPase
3by4, 3c0r - yUSP OTU domain + Ub
3znh – USP + Ub – Crimean-Congo hemorrhagic fever virus
RedJ TE
3qmv, 3qmw – TE – Streptomyces coelicolor
Orf6 TE
4i45 – TE – Photobacterium profundum
2av9, 2o5u, 2o6b, 2o6t, 2o6u, 3qy3 – TE – Pseudomonas aeruginosa
