3vtx
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Crystal structure of MamA protein== | |
| - | === | + | <StructureSection load='3vtx' size='340' side='right' caption='[[3vtx]], [[Resolution|resolution]] 1.75Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3vtx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candidatus_magnetobacterium_bavaricum Candidatus magnetobacterium bavaricum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VTX FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vty|3vty]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MamA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29290 Candidatus Magnetobacterium bavaricum])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vtx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vtx RCSB], [http://www.ebi.ac.uk/pdbsum/3vtx PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Magnetotactic bacteria enclose the magnetosome, a unique prokaryotic sub-cellular organelle that allows the biomineralization of magnetic nano-crystals. Membrane-coated magnetosomes are arranged into a linear chain that permits magnetotactic bacteria to navigate geomagnetic fields. Magnetosome assembly and biomineralization are controlled by conserved magnetosome-associated proteins, including MamA, a tetra-trico-peptide repeat (TPR)-containing protein that was shown to coat the magnetosome membrane. In this study, two MamA structures from Candidatus Magnetobacterium bavaricum (Mbav) were determined via X-ray crystallography. These structures confirm that Mbav MamA folds as a sequential TPR protein and shares a high degree of structural similarity with homologous MamA proteins from Magnetospirillum species. Furthermore, the two TPR-containing domains of MamA are separated by an interphylum-conserved region containing a flexible hinge that is involved in ligand binding and recognition. Finally, substantial differences were found in the local stabilization of the MamA N-terminal domain as a result of the loss of an evolutionary conserved salt bridge. | ||
| - | + | Inter-phylum structural conservation of the magnetosome-associated TPR-containing protein, MamA.,Zeytuni N, Baran D, Davidov G, Zarivach R J Struct Biol. 2012 Dec;180(3):479-87. doi: 10.1016/j.jsb.2012.08.001. Epub 2012 , Aug 15. PMID:22917855<ref>PMID:22917855</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Candidatus magnetobacterium bavaricum]] | [[Category: Candidatus magnetobacterium bavaricum]] | ||
| - | [[Category: Baran, D | + | [[Category: Baran, D]] |
| - | [[Category: Davidov, G | + | [[Category: Davidov, G]] |
| - | [[Category: Zarivach, R | + | [[Category: Zarivach, R]] |
| - | [[Category: Zeytuni, N | + | [[Category: Zeytuni, N]] |
[[Category: Peptide binding protein]] | [[Category: Peptide binding protein]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 07:37, 21 December 2014
Crystal structure of MamA protein
| |||||||||||
