4lrr

(Difference between revisions)

Revision as of 07:51, 6 November 2013

[TYSY_ECO57] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

4lrr is a 1 chain structure with sequence from Escherichia coli o157:h7. Full crystallographic information is available from OCA.

Ferrari S, Calo S, Leone R, Luciani R, Costantino L, Sammak S, Di Pisa F, Pozzi C, Mangani S, Costi MP. 2'-deoxyuridine-5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives. J Med Chem. 2013 Oct 22. PMID:24147825 doi:http://dx.doi.org/10.1021/jm4014086

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-'''Unreleased structure'''
+{{STRUCTURE_4lrr|  PDB=4lrr  |  SCENE=  }}
+===Ternary complex between E. coli thymidylate synthase, dUMP, and F9===
+{{ABSTRACT_PUBMED_24147825}}
-The entry 4lrr is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/TYSY_ECO57 TYSY_ECO57]] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
-Authors: Mangani, S., Pozzi, C., Ferrari, S., Costi, M.P.
+==About this Structure==
+[[4lrr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRR OCA].
-Description: Ternary complex between E. coli thymidylate synthase, dUMP, and F9
+==Reference==
+<ref group="xtra">PMID:024147825</ref><references group="xtra"/><references/>
+[[Category: Escherichia coli o157:h7]]
+[[Category: Thymidylate synthase]]
+[[Category: Costi, M P.]]
+[[Category: Ferrari, S.]]
+[[Category: Mangani, S.]]
+[[Category: Pozzi, C.]]
+[[Category: Beta-mercaptoethanol modified cysteine]]
+[[Category: N-terminal acetylated methionine]]
+[[Category: Thymidine monophosphate synthesis]]
+[[Category: Transferase]]