4m0e

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'''Unreleased structure'''
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{{STRUCTURE_4m0e| PDB=4m0e | SCENE= }}
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===Structure of human acetylcholinesterase in complex with dihydrotanshinone I===
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The entry 4m0e is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
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Authors: Cheung, J., Gary, E.N., Shiomi, K., Rosenberry, T.L.
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==About this Structure==
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[[4m0e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M0E OCA].
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Description: Structure of human acetylcholinesterase in complex with dihydrotanshinone I
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Acetylcholinesterase]]
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[[Category: Homo sapiens]]
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[[Category: Cheung, J.]]
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[[Category: Gary, E N.]]
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[[Category: Rosenberry, T L.]]
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[[Category: Shiomi, K.]]
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[[Category: Acetylcholinesterase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 08:10, 16 October 2013

Template:STRUCTURE 4m0e

Contents

Structure of human acetylcholinesterase in complex with dihydrotanshinone I

Function

[ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.[1] [2] [3] [4]

About this Structure

4m0e is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Chhajlani V, Derr D, Earles B, Schmell E, August T. Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase. FEBS Lett. 1989 Apr 24;247(2):279-82. PMID:2714437
  2. ↑ Velan B, Grosfeld H, Kronman C, Leitner M, Gozes Y, Lazar A, Flashner Y, Marcus D, Cohen S, Shafferman A. The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant. J Biol Chem. 1991 Dec 15;266(35):23977-84. PMID:1748670
  3. ↑ Shafferman A, Kronman C, Flashner Y, Leitner M, Grosfeld H, Ordentlich A, Gozes Y, Cohen S, Ariel N, Barak D, et al.. Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. J Biol Chem. 1992 Sep 5;267(25):17640-8. PMID:1517212
  4. ↑ Yang L, He HY, Zhang XJ. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neurosci Res. 2002 Apr;42(4):261-8. PMID:11985878

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