4ld9

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{{STRUCTURE_4ld9| PDB=4ld9 | SCENE= }}
{{STRUCTURE_4ld9| PDB=4ld9 | SCENE= }}
===Crystal structure of the N-terminally acetylated BAH domain of Sir3 bound to the nucleosome core particle===
===Crystal structure of the N-terminally acetylated BAH domain of Sir3 bound to the nucleosome core particle===
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{{ABSTRACT_PUBMED_23934150}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
[[4ld9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LD9 OCA].
[[4ld9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LD9 OCA].
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==Reference==
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<ref group="xtra">PMID:023934150</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]

Revision as of 05:14, 28 August 2013

Template:STRUCTURE 4ld9

Contents

Crystal structure of the N-terminally acetylated BAH domain of Sir3 bound to the nucleosome core particle

Template:ABSTRACT PUBMED 23934150

Function

[H2B11_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [SIR3_YEAST] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form. [H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

About this Structure

4ld9 is a 12 chain structure with sequence from Saccharomyces cerevisiae s288c and Xenopus laevis. Full crystallographic information is available from OCA.

Reference

  • Arnaudo N, Fernandez IS, McLaughlin SH, Peak-Chew SY, Rhodes D, Martino F. The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle. Nat Struct Mol Biol. 2013 Aug 11. doi: 10.1038/nsmb.2641. PMID:23934150 doi:10.1038/nsmb.2641

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