4c0f
From Proteopedia
| Line 1: | Line 1: | ||
| - | + | {{STRUCTURE_4c0f| PDB=4c0f | SCENE= }} | |
| + | ===Structure of the NOT-box domain of human CNOT2=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CNOT2_HUMAN CNOT2_HUMAN]] Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.<ref>PMID:14707134</ref> <ref>PMID:16712523</ref> <ref>PMID:21299754</ref> <ref>PMID:22367759</ref> | ||
| - | + | ==About this Structure== | |
| + | [[4c0f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0F OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Boland, A.]] | ||
| + | [[Category: Chen, Y.]] | ||
| + | [[Category: Izaurralde, E.]] | ||
| + | [[Category: Jonas, S.]] | ||
| + | [[Category: Raisch, T.]] | ||
| + | [[Category: Weichenrieder, O.]] | ||
| + | [[Category: Ccr4-not]] | ||
| + | [[Category: Deadenylation]] | ||
| + | [[Category: Gene regulation]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Mrna decay]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 06:34, 10 October 2013
Contents |
Structure of the NOT-box domain of human CNOT2
Function
[CNOT2_HUMAN] Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.[1] [2] [3] [4]
About this Structure
4c0f is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Zwartjes CG, Jayne S, van den Berg DL, Timmers HT. Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex. J Biol Chem. 2004 Mar 19;279(12):10848-54. Epub 2004 Jan 5. PMID:14707134 doi:http://dx.doi.org/10.1074/jbc.M311747200
- ↑ Jayne S, Zwartjes CG, van Schaik FM, Timmers HT. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Biochem J. 2006 Sep 15;398(3):461-7. PMID:16712523 doi:http://dx.doi.org/10.1042/BJ20060406
- ↑ Ito K, Inoue T, Yokoyama K, Morita M, Suzuki T, Yamamoto T. CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. Genes Cells. 2011 Apr;16(4):368-79. doi: 10.1111/j.1365-2443.2011.01492.x. Epub, 2011 Feb 8. PMID:21299754 doi:http://dx.doi.org/10.1111/j.1365-2443.2011.01492.x
- ↑ Zheng X, Dumitru R, Lackford BL, Freudenberg JM, Singh AP, Archer TK, Jothi R, Hu G. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Stem Cells. 2012 May;30(5):910-22. doi: 10.1002/stem.1070. PMID:22367759 doi:http://dx.doi.org/10.1002/stem.1070
