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Glycosyltransferase
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{{STRUCTURE_1cxh| PDB=1cxh | SIZE=400| SCENE= |right|CAPTION=Cyclodextrin glycosyltransferase complex with substrate maltoheptaose and Ca+2 ion, [[1cxh]] }} | {{STRUCTURE_1cxh| PDB=1cxh | SIZE=400| SCENE= |right|CAPTION=Cyclodextrin glycosyltransferase complex with substrate maltoheptaose and Ca+2 ion, [[1cxh]] }} | ||
| - | '''Glycosyltransferase''' (GT) are enzymes which catalyze the transfer of monosaccharide to alcohol, carbohydrate, protein or inorganic phosphate. '''Galactosyltransferase''' (AGT) is a GT which catalyzes the transfer of galactose during the synthesis of polysaccharides. '''Fucosylglycoprotein 3-AGT''' (GTB) or histo-blood group ABO system transferase is the basis of the blood ABO system. It involves 3 carbohydrate antigens: A, B and H. Individuals with blood type A, B and AB has glycosyltransferase activitiy which converts antigen H to A or B. Individuals with blood type O lack this activity. | + | '''Glycosyltransferase''' (GT) are enzymes which catalyze the transfer of monosaccharide to alcohol, carbohydrate, protein or inorganic phosphate. '''Galactosyltransferase''' (AGT) is a GT which catalyzes the transfer of galactose during the synthesis of polysaccharides. '''Fucosylglycoprotein 3-AGT''' (GTB) or '''histo-blood group ABO system transferase''' is the basis of the blood ABO system. It involves 3 carbohydrate antigens: A, B and H. Individuals with blood type A, B and AB has glycosyltransferase activitiy which converts antigen H to A or B. Individuals with blood type O lack this activity. |
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Revision as of 09:31, 22 August 2013
Glycosyltransferase (GT) are enzymes which catalyze the transfer of monosaccharide to alcohol, carbohydrate, protein or inorganic phosphate. Galactosyltransferase (AGT) is a GT which catalyzes the transfer of galactose during the synthesis of polysaccharides. Fucosylglycoprotein 3-AGT (GTB) or histo-blood group ABO system transferase is the basis of the blood ABO system. It involves 3 carbohydrate antigens: A, B and H. Individuals with blood type A, B and AB has glycosyltransferase activitiy which converts antigen H to A or B. Individuals with blood type O lack this activity.
3D structures of glycosyltransferase
Updated on 22-August-2013
Cyclodextrin GT (CGT)
1cxi, 1cdg, 1cgt, 1cgu - BcCGT – Bacillus circulans
1tcm, 4cgt, 7cgt, 1kck, 1kcl, 1ot1, 1ot2, 1pez, 1pj9, 1v3j, 1v3k, 1cgv, 1cgw - BcCGT (mutant)
1ciu – TtCGT – Thermoanaerobacterium thermosulfurigenes
3bmv, 3bmw – TtCGT (mutant)
1cyg – CGT – Geobacillus stearothermophilus
1d7f - BaCGT (mutant) – Bacillus
1pam - BaCGT
CGT binary complexes
1cxe, 1cxh – BcCGT + substrate
1cxf, 5cgt, 8cgt, 9cgt, 1cxk, 1eo5, 1eo7 - BcCGT (mutant) + substrate
3cgt - BcCGT (mutant) + β-cyclodextrin
1d3c - BcCGT (mutant) + γ-cyclodextrin
6cgt - BcCGT (mutant) + HOXA
2dij, 1dtu - BcCGT (mutant) + inhibitor
1cxl - BcCGT (mutant) + reaction intermediate
2cxg, 1ukq – BcCGT + acarbose-derivative
1uks, 1ukt, 1v3l, 1v3m – BcCGT (mutant) + acarbose-derivative
1ded - BaCGT (mutant) + acarbose
1i75 – BaCGT + deoxyjirimycin
1a47 – TtCGT + inhibitor
Maltose GT
1gju, 1lwh – TmMCG – Thermotoga maritima
1gjw – TmMCG + maltose
1lwj - TmMGT + acarbose
Human GT
1lz0 – hGT A - hGT A catalytic domain + inhibitor
1r7y, 1r81 - hGT A catalytic domain + inhibitor + UDP-derivative
1lz7 – hGT B catalytic domain
1r7u, 1r7x - hGT B catalytic domain + inhibitor
1r80, 1r82 - hGT B catalytic domain + inhibitor + UDP-derivative
1lzi – hGT A catalytic domain + UDP + H antigen acceptor
1lzj – hGT B catalytic domain + UDP + H antigen acceptor
1r7t, 1r7v - hGT ABO(H) + inhibitor
1wt0, 1wsz, 1wt3, 2o1f, 2o1g, 3i0c, 3i0h, 1xz6, 2i7b – hGT ABO(H) (mutant)
1wt1, 1wt2, 2o1h, 3i0d, 3i0i, 2y7a - hGT ABO(H) (mutant) + UDP
3i0e, 3i0j - hGT ABO(H) (mutant) + H-antigen
3i0f, 3i0k - hGT ABO(H) (mutant) + H-antigen + UDP
3i0g, 3i0l - hGT ABO(H) (mutant) + DA + UDP-Gal
Oleandomycin GT
2iya, 2iyf – GT – Strepromyces antibioticus
Hydroquinone GT
2vce – AtGT – Arabidopsis thaliana
2vch, 2vg8 – AtGT + UDP
Flavonoid GT
3hbf – MtGT + UDP + myricetin – Medicago truncatula
3hbj - MtGT + UDP
2pq6 - MtGT
2c1x, 2c1z – GT + UDP – Vitis vinifera
Various GT
1nzd – T4β-GT + UDP-glucose – Phage T4
2nzf, 1nzf - T4β-GT (mutant) + UDP-glucose
2iuy, 2iv3 – SvGT – Stretptomyces viridochromogenes
3hzs, 3vmq – SaGT – Staphylococcus aureus
3vmr, 3vms, 3vmt – SaGT + lipid II analog
3mbo – BaGT + UDP + malate – Bacillus anthracis
2jjm - BaGT
3oy7 – GT + GDP-mannose – cholera virus
3pnn – GT – Porphyromonas gingivalis
2q3e, 3q3i, 3q3e – ApGT – Actinobacillus pleuropneumomiae
3q3h – ApGT + UDP-Glc
1iir – AoUDP-GT – Amycolatopsis orientalis
1pn3, 1pnv, 1rrv – AoGT + TDP + vancomycin
2yjn – GT + Dtpd-4-keto-6-deoxy-hexose isomerase – Saccharopolyspora erythraea
1cwy – GT – Thermus aquaticus
2iv7, 2iw1 – GT - Escherichia coli
2xci – AaGT – Aquifex aeolicus
2xcu – AaGT + CMP
3ia7 – MeGT Calg4 – Micromonospora echinospora
3iaa – MeGT Calg2 + TDP
3rsc - MeGT Calg2 + TDP + calicheamicin
3otk – GT catalytic domain - mouse
4ayj – BoGT + glucose + galactose + fucose – Bacterioides ovatus
4ayl - BoGT
1g9r - GT (mutant) + UDP-galactose + Mn – Neisseria meningitides
β-1,4-galactosyltransferase (BGT)
1fgx - bBGT catalytic domain – bovine
1pzt - bBGT catalytic domain (mutant)
2fy7 - hBGT catalytic domain (mutant)
3lw6 - BGT catalytic domain (mutant) – Drosophila melanogaster
BGT binary complexes
1fr8, 1o0r - bBGT catalytic domain + UDP-galactose
1tvy, 1tw1 - bBGT catalytic domain (mutant) + UDP-galactose
1tw5 - bBGT catalytic domain (mutant) + chitobiose
1nf5 - bBGT + α-lactalbumin
1o23 - bBGT catalytic domain + UDP-glucose
1oqm - bBGT catalytic domain + UDP-N-acetylgalactosamine
2fya - hBGT catalytic domain (mutant) + Mn
4ee3, 4ee4, 4ee5, 4eea, 4eeg, 4eem, 4eeo - hBGT catalytic domain (mutant) + polysaccharide
BGT ternary complexes
1nhe, 1nkh - bBGT catalytic domain + UDP + α-lactalbumin
1yro - bBGT catalytic domain (mutant) + UDP-galactose + α-lactalbumin
1nwg - bBGT catalytic domain + N-butanoyl-glucoamine + α-lactalbumin
1nmm, 1nqi, 1pzy, 1o7q - bBGT catalytic domain + UDP + GlcNAc
2fyb - hBGT catalytic domain (mutant) + Mn + UDP
2ae7- hBGT catalytic domain + UDP + pentasaccharide
2aec, 2aes, 2agd - hBGT catalytic domain + UDP + GlcNAc + mannose
2fyc - hBGT catalytic domain (mutant) + UDP-galactose + Ca + α-lactalbumin
3ee5 - hBGT catalytic domain (mutant) + UDP + GlcNAc-β1,3-gal-β-naphthalenemethanol
2fyd - hBGT catalytic domain + UDP-GlcNAc + Mn + α-lactalbumin
(mutant) + glucose
2ah9 - hBGT catalytic domain + UDP + chitotriose
α-1,3-galactosyltransferase (AGT)
1g8o, 1fg5, 2jco - bAGT catalytic domain
2jcl – bAGT catalytic domain (mutant)
1vzu, 1vzx, 2i7b - hAGT catalytic domain (mutant)
2i7b - hAGT catalytic domain (mutant)
AGT binary complexes
1g93, 1gx0 - bAGT catalytic domain + UDP-galactose
1k4v - bAGT catalytic domain + UDP
2rj0 - bAGT catalytic domain + UDP + Mn
1vzt, 2jcj - bAGT catalytic domain (mutant) + UDP
2vfz - bAGT catalytic domain (mutant) + UDP-2F-galactose
2vs4, 2vs5, 2vxl, 2vxm, 2vs3 - bAGT catalytic domain (mutant) + UDP-galactose
2vs3 - bAGT catalytic domain + UDP-galactose
1ziz, 1zjp - hAGT catalytic domain + galactose
1zj0 - hAGT catalytic domain + lactose
1zj1 - hAGT catalytic domain + N-acetyl lactosamine
1zj2, 1zj3 - hAGT catalytic domain + trisaccharide
2a8u, 2a8w - hAGT catalytic domain + methyl lactoside
AGT ternary complexes
1gwv - bAGT catalytic domain + UDP + lactose
2jck - bAGT catalytic domain (mutant) + UDP + Mn
2wgz - bAGT catalytic domain + UDP + nitrophenyl-β-galactoside
1o7o - bAGT catalytic domain (mutant) + UDP + lactose
1gx4 - bAGT catalytic domain + UDP + N-acetyl lactosamine
1gww - bAGT catalytic domain + UDP + glucose
1r7u, 1r7x - hAGT catalytic domain + inhibitor + fucose
1r80 - hAGT catalytic domain + UDP + inhibitor + fucose
1r82 - hAGT catalytic domain + UDP-galactose + inhibitor + fucose
Fucosylglycoprotein 3-AGT (GTB)
2pgv, 2pgy, 2riz, 2rj5, 1wsz, 2o1f, 2o1g – hGTB (mutant)
2rit – hGTB
2rix – hGTB + UDP
2o1h – hGT Abo (mutant) + UDP
2riy – hGTB + H-antigen acceptor
1zi4, 1zi5 - hGTB + H-antigen
3i0j – hGT Abo (mutant) + H-antigen
2rj1, 2rj6 - hGTB (mutant) + UDP + H-antigen disaccharide
2rj8 - hGTB + UDP + H-antigen disaccharide
2rj4 - hGTB (mutant) + UDP + ADA
2rj7 - hGTB (mutant) + UDP-galactose + deoxy-acceptor
2rj9 - hGTB + UDP-galactose + deoxy-acceptor
3sx3, 3sx5, 3sx7, 3sx8, 3sxc, 3sxd, 3sxe, 3sxg, 1zhj, 1zjo - hAGT catalytic domain + galactose
1zi1 - hAGT catalytic domain + lactose
1zi3 - hAGT catalytic domain + acetylactosamine
Fucosylgalactoside α N-acetylgalactosaminyltrasferase (GTA)
3ioh – hGTA (mutant)
3ioi - hGTA (mutant) + UDP-galactose derivative
3ioj - hGTA (mutant) + UDP
