Adaptin

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<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α (grey), AP-β (light green), AP-μ (green), AP-σ (olive green) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene=''>
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<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (grey), AP-β-1 (light green), AP-μ-1 (green), AP-σ-1 (olive green) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene=''>
'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a hetertetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.
'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a hetertetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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'''AP-α'''
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'''AP-α-2'''
[[1b9x]], [[1qts]] – mAP appendage domain – mouse<br />
[[1b9x]], [[1qts]] – mAP appendage domain – mouse<br />
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'''AP-β'''
'''AP-β'''
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[[1e42]] - hAP appendage domain - human<br />
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[[1e42]] – hAP-1 appendage domain - human<br />
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[[2g30]] – hAP appendage domain + ARH peptide<br />
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[[2g30]] – hAP-1 appendage domain + ARH peptide<br />
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[[2iv9]] – hAP appendage domain + eps15 peptide<br />
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[[3h1z]] – hAP-1 appendage domain + PTDINSPKI-γ peptide<br />
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[[2iv8]] – hAP appendage domain + B-arrestin peptide<br />
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[[3hs9]] – hAP-1 appendage domain + intersectin peptide<br />
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[[3h1z]] – hAP appendage domain + PTDINSPKI-γ peptide<br />
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[[2iv9]] – hAP-2 appendage domain + eps15 peptide<br />
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[[3hs9]] – hAP appendage domain + intersectin peptide<br />
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[[2iv8]] – hAP-2 appendage domain + B-arrestin peptide<br />
'''AP-γ'''
'''AP-γ'''
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[[1iu1]], [[2e9g]], [[4bcx]] – hAP ear domain<br />
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[[1iu1]] – hAP-1 ear domain<br />
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[[2ymt]] – hAP ear domain + peptide<br />
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[[1gyu]], [[2a7b]] – mAP-1 appendage domain <br />
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[[3zhf]] – hAP ear domain + large envelope protein peptide<br />
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[[1gyv]], [[1gyw]], [[3zy7]] – mAP-1 appendage domain (mutant)<br />
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[[1gyu]], [[2a7b]] – mAP appendage domain <br />
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[[2e9g]], [[4bcx]] – hAP-2 ear domain<br />
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[[1gyv]], [[1gyw]], [[3zy7]] – mAP appendage domain (mutant)<br />
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[[2ymt]] – hAP-2 ear domain + peptide<br />
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[[3zhf]] – hAP-2 ear domain + large envelope protein peptide<br />
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'''AP-δ'''
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'''AP-δ-1'''
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[[4afi]] – hAP/vesicle-associated membrane protein 7<br />
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[[4afi]] – hAP-1/vesicle-associated membrane protein 7<br />
'''AP-μ'''
'''AP-μ'''
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[[1bw8]], [[1i31]] – rAP + EGFR peptide<br />
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[[3h85]] – rAP-1 appendage domain + PTDINSPKIγ peptide<br />
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[[1bxx]] – rAP + TGN38 peptide<br />
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[[4emz]], [[4en2]] – mAP-1 sorting motif recognition domain + nef + MHC-I<br />
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[[1hes]] – rAP + selectin peptide<br />
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[[1bw8]], [[1i31]] – rAP-2 + EGFR peptide<br />
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[[2bp5]] – rAP + purinoceptor peptide<br />
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[[1bxx]] – rAP-2 + TGN38 peptide<br />
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[[2pr9]] – rAP + GABA receptor peptide<br />
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[[1hes]] – rAP-2 + selectin peptide<br />
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[[3h85]] – rAP appendage domain + PTDINSPKIgamma peptide<br />
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[[2bp5]] – rAP-2 + purinoceptor peptide<br />
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[[4emz]], [[4en2]] – mAP sorting motif recognition domain + nef + MHC-I<br />
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[[2pr9]] – rAP-2 + GABA receptor peptide<br />
'''AP-α + AP-β + AP-μ + AP-σ'''
'''AP-α + AP-β + AP-μ + AP-σ'''
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[[2vgl]] – rAPα + APβ + APμ + APσ <br />
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[[2vgl]] – rAPα-2 + APβ-1 + APμ-1 + APσ-1 <br />
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[[2jkr]], [[2jkt]] – mAPα + APβ + APμ + APσ + CD4 peptide<br />
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[[2jkr]], [[2jkt]] – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide<br />
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[[2xa7]] – rAPα + APβ + APμ + APσ + cargo peptide<br />
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[[2xa7]] – rAPα-2 + APβ + APμ + APσ + cargo peptide<br />
'''AP-γ + AP-β + AP-μ + AP-σ'''
'''AP-γ + AP-β + AP-μ + AP-σ'''
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[[1w63]] – mAPγ + APβ + APμ + APσ <br />
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[[1w63]] – mAPγ-1 + APβ-1 + APμ-1 + APσ-1A <br />
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[[4hmy]] – mAPγ + APβ + APμ + APσ + ADP-ribosylation factor<br />
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[[4hmy]] – mAPγ-1 + APβ-1 + APμ-1 + APσ-3 + ADP-ribosylation factor<br />
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[[Category:Topic Page]]

Revision as of 06:40, 30 June 2014

Structure of Adaptin core: AP-α-2 (grey), AP-β-1 (light green), AP-μ-1 (green), AP-σ-1 (olive green) complex with inositole hexakisphosphate (PDB entry 2vgl)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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