Sandbox Mati
From Proteopedia
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| - | Bcl-Xl is a member of the [http://en.wikipedia.org/wiki/Bcl-2 Bcl-2 family] . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl as <Structure load='2yxj_With_Ligand_Mati_Cohen.pdb' size='500' frame='true' align='right' caption=' | + | Bcl-Xl is a member of the [http://en.wikipedia.org/wiki/Bcl-2 Bcl-2 family] . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl as can be seen in the image <Structure load='2yxj_With_Ligand_Mati_Cohen.pdb' size='500' frame='true' align='right' caption='Bcl-Xl and ABT737 from PDBID 2yxj' scene='Insert optional scene name here' /> .an anti a poptotivc protein binds pro apoptotic proteins like BAK and BAD thus inhibiting program cell death. Many cancer cells overexpress at least one of the anti-apoptotic members of this family , thus escaping apoptosis . Therefore these proteins are important targets for the development of new anti-cancer drugs. |
Revision as of 19:43, 27 August 2013
Bcl-Xl is a member of the Bcl-2 family . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl as can be seen in the image
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