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Sandbox Mati

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Interestingly the interface of Bcl-Xl is almost symmetric. There are <scene name='43/437742/2yxj_arg/2'>two positively charged residues</scene> Arg 100 and Arg 139.
Interestingly the interface of Bcl-Xl is almost symmetric. There are <scene name='43/437742/2yxj_arg/2'>two positively charged residues</scene> Arg 100 and Arg 139.
<scene name='43/437742/2yxj_glu/1'>two negativly charged residues</scene> Glu 96 and Glu 129.
<scene name='43/437742/2yxj_glu/1'>two negativly charged residues</scene> Glu 96 and Glu 129.
 +
<scene name='43/437742/2yxj_hydrophobic/1'>hydrophobic patches</scene>

Revision as of 06:37, 28 August 2013

Bcl-Xl is a member of the Bcl-2 family . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl(in the image)

Bcl-Xl and ABT737 from PDB-ID 2yxj

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,an anti apoptotic protein, binds pro apoptotic proteins like BAK and BAD thus inhibiting program cell death. Many cancer cells overexpress at least one of the anti-apoptotic members of this family , thus escaping apoptosis . Therefore these proteins are important targets for the development of new anti-cancer drugs.

the PDB file 2yxjshows the structure of Bcl-Xl and ABT 737. ABT 737 is a sub nano Molar inhibitor of Bcl-Xl. It binds Bcl-xl in the same position as BAK does as can be seen in 1bxl. Interestingly the interface of Bcl-Xl is almost symmetric. There are Arg 100 and Arg 139. Glu 96 and Glu 129.

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