Sandbox Mati

From Proteopedia

proteopedia linkproteopedia link

Revision as of 20:37, 27 August 2013 (edit) Mati Cohen (Talk | contribs) ← Previous diff		Revision as of 06:37, 28 August 2013 (edit) (undo) Mati Cohen (Talk | contribs) Next diff →
Line 3:		Line 3:
	Interestingly the interface of Bcl-Xl is almost symmetric. There are <scene name='43/437742/2yxj_arg/2'>two positively charged residues</scene> Arg 100 and Arg 139.		Interestingly the interface of Bcl-Xl is almost symmetric. There are <scene name='43/437742/2yxj_arg/2'>two positively charged residues</scene> Arg 100 and Arg 139.
	<scene name='43/437742/2yxj_glu/1'>two negativly charged residues</scene> Glu 96 and Glu 129.		<scene name='43/437742/2yxj_glu/1'>two negativly charged residues</scene> Glu 96 and Glu 129.
		+	<scene name='43/437742/2yxj_hydrophobic/1'>hydrophobic patches</scene>

---

Revision as of 06:37, 28 August 2013

Bcl-Xl is a member of the Bcl-2 family . This family consists of pro-apoptotic and anti-apoptotic members. Bcl-Xl(in the image)

spinqualitylabelsall models Bcl-Xl and ABT737 from PDB-ID 2yxj Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

,an anti apoptotic protein, binds pro apoptotic proteins like BAK and BAD thus inhibiting program cell death. Many cancer cells overexpress at least one of the anti-apoptotic members of this family , thus escaping apoptosis . Therefore these proteins are important targets for the development of new anti-cancer drugs.

the PDB file 2yxjshows the structure of Bcl-Xl and ABT 737. ABT 737 is a sub nano Molar inhibitor of Bcl-Xl. It binds Bcl-xl in the same position as BAK does as can be seen in 1bxl. Interestingly the interface of Bcl-Xl is almost symmetric. There are Arg 100 and Arg 139. Glu 96 and Glu 129.