2mib

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[[Image:2mib.jpg|left|200px]]<br /><applet load="2mib" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2mib.jpg|left|200px]]
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caption="2mib, resolution 2.84&Aring;" />
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'''THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION'''<br />
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{{Structure
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|PDB= 2mib |SIZE=350|CAPTION= <scene name='initialview01'>2mib</scene>, resolution 2.84&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2MIB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIB OCA].
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2MIB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIB OCA].
==Reference==
==Reference==
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The structure of murine interleukin-1 beta at 2.8 A resolution., van Oostrum J, Priestle JP, Grutter MG, Schmitz A, J Struct Biol. 1991 Oct;107(2):189-95. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1807351 1807351]
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The structure of murine interleukin-1 beta at 2.8 A resolution., van Oostrum J, Priestle JP, Grutter MG, Schmitz A, J Struct Biol. 1991 Oct;107(2):189-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1807351 1807351]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: cytokine]]
[[Category: cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:07:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:47:22 2008''

Revision as of 15:47, 20 March 2008

Image:2mib.jpg


PDB ID 2mib

Drag the structure with the mouse to rotate
, resolution 2.84Å
Coordinates: save as pdb, mmCIF, xml



THE STRUCTURE OF MURINE INTERLEUKIN-1 BETA AT 2.8 ANGSTROMS RESOLUTION


Overview

The three-dimensional structure of recombinant murine interleukin-1 beta has been solved by X-ray crystallographic techniques to 2.8 A resolution and refined to a crystallographic R factor of 0.192. Although murine interleukin-1 beta crystallizes in the same space group as human interleukin-1 beta with almost identical unit cell dimensions, the packing of the molecules is quite different. The murine interleukin-1 beta structure was solved by molecular replacement using the refined structure of human interleukin-1 beta as trial structure, and found to be related to the human structure by a nearly perfect twofold rotation about the crystallographic y-axis and a 14 degrees rotation about the z-axis, with no translation. The folding of murine interleukin-1 beta is similar to that found for the human variant, consisting of 12 beta strands wrapped around a core of hydrophobic side chains in a tetrahedron-like fashion. Significant differences with respect to the human structure are seen at the N terminus and in 4 of the 11 loops connecting the 12 beta strands.

About this Structure

2MIB is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of murine interleukin-1 beta at 2.8 A resolution., van Oostrum J, Priestle JP, Grutter MG, Schmitz A, J Struct Biol. 1991 Oct;107(2):189-95. PMID:1807351

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