2nll

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[[Image:2nll.gif|left|200px]]<br /><applet load="2nll" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2nll.gif|left|200px]]
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caption="2nll, resolution 1.900&Aring;" />
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'''RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA'''<br />
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{{Structure
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|PDB= 2nll |SIZE=350|CAPTION= <scene name='initialview01'>2nll</scene>, resolution 1.900&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2NLL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLL OCA].
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2NLL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLL OCA].
==Reference==
==Reference==
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Structural determinants of nuclear receptor assembly on DNA direct repeats., Rastinejad F, Perlmann T, Evans RM, Sigler PB, Nature. 1995 May 18;375(6528):203-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7746322 7746322]
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Structural determinants of nuclear receptor assembly on DNA direct repeats., Rastinejad F, Perlmann T, Evans RM, Sigler PB, Nature. 1995 May 18;375(6528):203-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7746322 7746322]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: zinc- finger]]
[[Category: zinc- finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:08:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:48:06 2008''

Revision as of 15:48, 20 March 2008

Image:2nll.gif


PDB ID 2nll

Drag the structure with the mouse to rotate
, resolution 1.900Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA


Contents

Overview

Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs. The 1.9 A crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.

Disease

Known diseases associated with this structure: Thyroid hormone resistance OMIM:[190160], Thyroid hormone resistance, autosomal recessive OMIM:[190160]

About this Structure

2NLL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural determinants of nuclear receptor assembly on DNA direct repeats., Rastinejad F, Perlmann T, Evans RM, Sigler PB, Nature. 1995 May 18;375(6528):203-11. PMID:7746322

Page seeded by OCA on Thu Mar 20 17:48:06 2008

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