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4c28
From Proteopedia
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| - | ''' | + | ==Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)-2-fluorobenzamide.== |
| - | + | <StructureSection load='4c28' size='340' side='right' caption='[[4c28]], [[Resolution|resolution]] 2.03Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4c28]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C28 FirstGlance]. <br> | |
| - | + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TW5:(R)-N-(3-(1H-INDOL-3-YL)-1-OXO-1-(PYRIDIN-4-YLAMINO)PROPAN-2-YL)-4-(4-(4-CHLOROPHENYL)PIPERAZIN-1-YL)-2-FLUOROBENZAMIDE'>TW5</scene><br> | |
| - | + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c27|4c27]]</td></tr> | |
| - | + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr> | |
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c28 RCSB], [http://www.ebi.ac.uk/pdbsum/4c28 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Sterol 14-demethylase]] | ||
| + | [[Category: Calvet, C M.]] | ||
| + | [[Category: Cameron, M D.]] | ||
| + | [[Category: Choi, J Y.]] | ||
| + | [[Category: Gut, J.]] | ||
| + | [[Category: Kellar, D.]] | ||
| + | [[Category: McKerrow, J H.]] | ||
| + | [[Category: Podust, L M.]] | ||
| + | [[Category: Roush, W R.]] | ||
| + | [[Category: Siqueira-Neto, J L.]] | ||
| + | [[Category: Vieira, D F.]] | ||
| + | [[Category: Chagas disease]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Sterol biosynthesis]] | ||
Revision as of 06:03, 4 September 2014
Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(4-chlorophenyl)piperazin-1-yl)-2-fluorobenzamide.
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