4c2i

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m (Protected "4c2i" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4c2i| PDB=4c2i | SCENE= }}
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===Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4===
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{{ABSTRACT_PUBMED_24421336}}
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The entry 4c2i is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/Q7TGE4_9FLAV Q7TGE4_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS027287_004_099774] [[http://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
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Authors: Fibriansah, G., Tan, J.L., de Alwis, R., Smith, S.A., Ng, T.-S., Kostyuchenko, V.A., Ibarra, K.D., Harris, E., de Silva, A., Crowe Junior, J.E., Lok, S.-M.
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==About this Structure==
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[[4c2i]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_serotype_1 Dengue virus serotype 1] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2I OCA].
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Description: Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4
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==Reference==
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<ref group="xtra">PMID:024421336</ref><references group="xtra"/><references/>
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[[Category: Dengue virus serotype 1]]
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[[Category: Homo sapiens]]
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[[Category: Alwis, R de.]]
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[[Category: Fibriansah, G.]]
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[[Category: Harris, E.]]
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[[Category: Ibarra, K D.]]
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[[Category: Junior, J E.Crowe.]]
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[[Category: Kostyuchenko, V A.]]
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[[Category: Lok, S M.]]
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[[Category: Ng, T S.]]
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[[Category: Silva, A de.]]
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[[Category: Smith, S A.]]
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[[Category: Tan, J L.]]
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[[Category: E protein]]
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[[Category: Neutralization]]
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[[Category: Virus]]

Revision as of 07:34, 29 January 2014

Template:STRUCTURE 4c2i

Contents

Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4

Template:ABSTRACT PUBMED 24421336

Function

[Q7TGE4_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS027287_004_099774] [G3F5K5_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]

About this Structure

4c2i is a 10 chain structure with sequence from Dengue virus serotype 1 and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Fibriansah G, Tan JL, Smith SA, de Alwis AR, Ng TS, Kostyuchenko VA, Ibarra KD, Wang J, Harris E, de Silva A, Crowe JE Jr, Lok SM. A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface. EMBO Mol Med. 2014 Jan 13. PMID:24421336 doi:http://dx.doi.org/10.1002/emmm.201303404

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OCA

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