4c39

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m (Protected "4c39" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4c39| PDB=4c39 | SCENE= }}
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===Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine===
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{{ABSTRACT_PUBMED_24660051}}
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The entry 4c39 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
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Authors: Li, H., Poulos, T.L.
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==About this Structure==
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[[4c39]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C39 OCA].
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Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine
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==Reference==
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<ref group="xtra">PMID:024660051</ref><references group="xtra"/><references/>
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[[Category: Li, H.]]
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[[Category: Poulos, T L.]]
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[[Category: Inhibitor complex]]
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[[Category: Oxidoreductase]]

Revision as of 09:21, 2 April 2014

Template:STRUCTURE 4c39

Contents

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine

Template:ABSTRACT PUBMED 24660051

Function

[NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.

About this Structure

4c39 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Jing Q, Li H, Roman LJ, Martasek P, Poulos TL, Silverman RB. An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors. ACS Med Chem Lett. 2014 Jan 9;5(1):56-60. PMID:24660051 doi:http://dx.doi.org/10.1021/ml400381s

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OCA

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