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4mcb

From Proteopedia

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m (Protected "4mcb" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4mcb| PDB=4mcb | SCENE= }}
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===H.influenzae TrmD in complex with N-(4-{[(1H-IMIDAZOL-2-YLMETHYL)AMINO]METHYL}BENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE===
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{{ABSTRACT_PUBMED_23981144}}
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The entry 4mcb is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
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Authors: Olivier, N.B., Hill, P.
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==About this Structure==
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[[4mcb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae_rd_kw20 Haemophilus influenzae rd kw20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCB OCA].
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Description:
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==Reference==
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<ref group="xtra">PMID:023981144</ref><references group="xtra"/><references/>
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[[Category: Haemophilus influenzae rd kw20]]
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[[Category: Hill, P.]]
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[[Category: Olivier, N B.]]
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[[Category: Hmt]]
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[[Category: Methyl transferase to trna]]
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[[Category: Sah]]
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[[Category: Sam]]
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[[Category: Sinefungin]]
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[[Category: Structural genomic]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Trefoil]]
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[[Category: Trefoil knot]]
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[[Category: Trmd]]
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[[Category: Trna]]

Revision as of 10:48, 4 September 2013

Template:STRUCTURE 4mcb

Contents

H.influenzae TrmD in complex with N-(4-{[(1H-IMIDAZOL-2-YLMETHYL)AMINO]METHYL}BENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE

Template:ABSTRACT PUBMED 23981144

Function

[TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]

About this Structure

4mcb is a 2 chain structure with sequence from Haemophilus influenzae rd kw20. Full crystallographic information is available from OCA.

Reference

  • Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET. Selective Inhibitors of Bacterial t-RNA-(NG37) Methyltransferase (TrmD) that Demonstrate Novel Ordering of the Lid Domain. J Med Chem. 2013 Aug 27. PMID:23981144 doi:10.1021/jm400718n

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OCA

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