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4mcc

From Proteopedia

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m (Protected "4mcc" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4mcc| PDB=4mcc | SCENE= }}
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===HinTrmD in complex with N-[4-(AMINOMETHYL)BENZYL]-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE===
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{{ABSTRACT_PUBMED_23981144}}
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The entry 4mcc is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
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Authors: Olivier, N.B., Hill, P.
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==About this Structure==
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[[4mcc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae_rd_kw20 Haemophilus influenzae rd kw20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MCC OCA].
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Description:
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==Reference==
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<ref group="xtra">PMID:023981144</ref><references group="xtra"/><references/>
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[[Category: Haemophilus influenzae rd kw20]]
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[[Category: Hill, P.]]
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[[Category: Olivier, N B.]]
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[[Category: Hmt]]
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[[Category: N/a]]
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[[Category: Sah]]
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[[Category: Sam]]
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[[Category: Sinefungin]]
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[[Category: Structural genomic]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Trefoil]]
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[[Category: Trmd]]

Revision as of 10:44, 4 September 2013

Template:STRUCTURE 4mcc

Contents

HinTrmD in complex with N-[4-(AMINOMETHYL)BENZYL]-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE

Template:ABSTRACT PUBMED 23981144

Function

[TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]

About this Structure

4mcc is a 2 chain structure with sequence from Haemophilus influenzae rd kw20. Full crystallographic information is available from OCA.

Reference

  • Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET. Selective Inhibitors of Bacterial t-RNA-(NG37) Methyltransferase (TrmD) that Demonstrate Novel Ordering of the Lid Domain. J Med Chem. 2013 Aug 27. PMID:23981144 doi:10.1021/jm400718n

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OCA

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