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2mb3
From Proteopedia
(Difference between revisions)
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| - | + | ==Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative== | |
| - | + | <StructureSection load='2mb3' size='340' side='right' caption='[[2mb3]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2mb3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MB3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MB3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L2H:(12S,27S)-12,27-BIS(4-AMINOBUTYL)-4,30-DIMETHYL-3,7,14,18,22,29-HEXAOXA-11,26,31,32,33,34,35,36-OCTAAZAHEPTACYCLO[26.2.1.1~2,5~.1~6,9~.1~13,16~.1~17,20~.1~21,24~]HEXATRIACONTA-1(30),2(36),4,6(35),8,13(34),15,17(33),19,21(32),23,28(31)-DODECAENE-10,25-DIONE'>L2H</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mb3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mb3 RCSB], [http://www.ebi.ac.uk/pdbsum/2mb3 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Guanine-rich human telomeric DNA can adopt secondary structures known as G-quadruplexes, which can be targeted by small molecules to achieve anticancer effects. So far, the structural information on complexes between human telomeric DNA and ligands is limited to the parallel G-quadruplex conformation, despite the high structural polymorphism of human telomeric G-quadruplexes. No structure has been yet resolved for the complex with telomestatin, one of the most promising G-quadruplex-targeting anticancer drug candidates. Here we present the first high-resolution structure of the complex between an intramolecular (3+1) human telomeric G-quadruplex and a telomestatin derivative, the macrocyclic hexaoxazole L2H2-6M(2)OTD. This compound is observed to interact with the G-quadruplex through pi-stacking and electrostatic interactions. This structural information provides a platform for the design of topology-specific G-quadruplex-targeting compounds and is valuable for the development of new potent anticancer drugs. | ||
| - | + | Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative.,Chung WJ, Heddi B, Tera M, Iida K, Nagasawa K, Phan AT J Am Chem Soc. 2013 Aug 2. PMID:23909929<ref>PMID:23909929</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Chung, W J | + | == References == |
| - | [[Category: Heddi, B | + | <references/> |
| - | [[Category: Iida, K | + | __TOC__ |
| - | [[Category: Nagasawa, K | + | </StructureSection> |
| - | [[Category: Phan, A T | + | [[Category: Chung, W J]] |
| - | [[Category: Tera, M | + | [[Category: Heddi, B]] |
| + | [[Category: Iida, K]] | ||
| + | [[Category: Nagasawa, K]] | ||
| + | [[Category: Phan, A T]] | ||
| + | [[Category: Tera, M]] | ||
[[Category: Anticancer target]] | [[Category: Anticancer target]] | ||
[[Category: Dna-dna inhibitor complex]] | [[Category: Dna-dna inhibitor complex]] | ||
Revision as of 11:52, 18 December 2014
Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative
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