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4bex
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4bex| PDB=4bex | SCENE= }} | {{STRUCTURE_4bex| PDB=4bex | SCENE= }} | ||
===Structure of human Cofilin1=== | ===Structure of human Cofilin1=== | ||
| + | {{ABSTRACT_PUBMED_23999301}} | ||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:023999301</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Cameron, J.]] | ||
[[Category: Gabrielsen, M.]] | [[Category: Gabrielsen, M.]] | ||
| - | [[Category: | + | [[Category: Klejnot, M.]] |
[[Category: Kozielski, F.]] | [[Category: Kozielski, F.]] | ||
[[Category: Mleczaka, A.]] | [[Category: Mleczaka, A.]] | ||
[[Category: Olson, M F.]] | [[Category: Olson, M F.]] | ||
[[Category: Pannifer, A.]] | [[Category: Pannifer, A.]] | ||
| - | [[Category: Talapatra, S | + | [[Category: Talapatra, S K.]] |
| - | + | ||
[[Category: Actin-binding]] | [[Category: Actin-binding]] | ||
[[Category: Cytoskeleton]] | [[Category: Cytoskeleton]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Revision as of 04:03, 12 September 2013
Contents |
Structure of human Cofilin1
Template:ABSTRACT PUBMED 23999301
Function
[COF1_HUMAN] Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization.[1] [2]
About this Structure
4bex is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Klejnot M, Gabrielsen M, Cameron J, Mleczak A, Talapatra SK, Kozielski F, Pannifer A, Olson MF. Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding. Acta Crystallogr D Biol Crystallogr. 2013 Sep 1;69(Pt 9):1780-8. doi:, 10.1107/S0907444913014418. Epub 2013 Aug 17. PMID:23999301 doi:10.1107/S0907444913014418
- ↑ Gohla A, Birkenfeld J, Bokoch GM. Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol. 2005 Jan;7(1):21-9. Epub 2004 Dec 5. PMID:15580268 doi:10.1038/ncb1201
- ↑ Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V, Suryavanshi N, Bechtel S, Wiemann S, Baum B, Ridley AJ. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol. 2011 Aug 11;9:54. doi: 10.1186/1741-7007-9-54. PMID:21834987 doi:10.1186/1741-7007-9-54
