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4kwe
From Proteopedia
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| - | + | ==GDP-bound, double-stranded, curved FtsZ protofilament structure== | |
| - | + | <StructureSection load='4kwe' size='340' side='right' caption='[[4kwe]], [[Resolution|resolution]] 2.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4kwe]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KWE FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ftsZ, MT2209, MTCY270.18, Rv2150c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kwe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kwe RCSB], [http://www.ebi.ac.uk/pdbsum/4kwe PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The essential bacterial protein FtsZ is a guanosine triphosphatase that self-assembles into a structure at the division site termed the "Z ring". During cytokinesis, the Z ring exerts a constrictive force on the membrane by using the chemical energy of guanosine triphosphate hydrolysis. However, the structural basis of this constriction remains unresolved. Here, we present the crystal structure of a guanosine diphosphate-bound Mycobacterium tuberculosis FtsZ protofilament, which exhibits a curved conformational state. The structure reveals a longitudinal interface that is important for function. The protofilament curvature highlights a hydrolysis-dependent conformational switch at the T3 loop that leads to longitudinal bending between subunits, which could generate sufficient force to drive cytokinesis. | ||
| - | + | FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation.,Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC, Wang HW, Ye S Science. 2013 Jul 26;341(6144):392-5. doi: 10.1126/science.1239248. PMID:23888039<ref>PMID:23888039</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
*[[Cell division protein Ftsz|Cell division protein Ftsz]] | *[[Cell division protein Ftsz|Cell division protein Ftsz]] | ||
| - | + | *[[Tubulin|Tubulin]] | |
| - | == | + | == References == |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: Cheng, Y | + | [[Category: Cheng, Y]] |
| - | [[Category: Hsin, J | + | [[Category: Hsin, J]] |
| - | [[Category: Huang, K C | + | [[Category: Huang, K C]] |
| - | [[Category: Li, Y | + | [[Category: Li, Y]] |
| - | [[Category: Shang, W | + | [[Category: Shang, W]] |
| - | [[Category: Wang, H W | + | [[Category: Wang, H W]] |
| - | [[Category: Ye, S | + | [[Category: Ye, S]] |
| - | [[Category: Zhao, L | + | [[Category: Zhao, L]] |
[[Category: Bacterial cell division]] | [[Category: Bacterial cell division]] | ||
[[Category: Gtp-binding protein]] | [[Category: Gtp-binding protein]] | ||
[[Category: Rossmann fold]] | [[Category: Rossmann fold]] | ||
Revision as of 15:30, 21 December 2014
GDP-bound, double-stranded, curved FtsZ protofilament structure
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