4c3a

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'''Unreleased structure'''
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{{STRUCTURE_4c3a| PDB=4c3a | SCENE= }}
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===Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy) methyl)-4-methylpyridin-2-amine===
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{{ABSTRACT_PUBMED_24660051}}
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The entry 4c3a is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
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Authors: Li, H., Poulos, T.L.
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==About this Structure==
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[[4c3a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3A OCA].
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Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy) methyl)-4-methylpyridin-2-amine
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==Reference==
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<ref group="xtra">PMID:024660051</ref><references group="xtra"/><references/>
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[[Category: Li, H.]]
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[[Category: Poulos, T L.]]
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[[Category: Inhibitor complex]]
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[[Category: Oxidoreductase]]

Revision as of 09:23, 2 April 2014

Template:STRUCTURE 4c3a

Contents

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy) methyl)-4-methylpyridin-2-amine

Template:ABSTRACT PUBMED 24660051

Function

[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

About this Structure

4c3a is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Jing Q, Li H, Roman LJ, Martasek P, Poulos TL, Silverman RB. An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors. ACS Med Chem Lett. 2014 Jan 9;5(1):56-60. PMID:24660051 doi:http://dx.doi.org/10.1021/ml400381s

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OCA

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