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4c3e

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'''Unreleased structure'''
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{{STRUCTURE_4c3e| PDB=4c3e | SCENE= }}
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===HRSV M2-1 mutant S58D S61D, P21 crystal===
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The entry 4c3e is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/M21_HRSVA M21_HRSVA]] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.<ref>PMID:8552680</ref> <ref>PMID:9420254</ref> <ref>PMID:10364337</ref>
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Authors: Tanner, S.J., Ariza, A., Richard, C.A., Wu, W., Trincao, J., Hiscox, J.A., Carroll, M., Sillman, N., Eleouet, J.F., Edwards, T.A., Barr, J.N.
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==About this Structure==
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[[4c3e]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3E OCA].
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Description: HRSV M2-1 mutant S58D S61D, P21 crystal
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Ariza, A.]]
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[[Category: Barr, J N.]]
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[[Category: Carroll, M W.]]
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[[Category: Edwards, T A.]]
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[[Category: Eleouet, J F.]]
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[[Category: Hiscox, J A.]]
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[[Category: Richard, C A.]]
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[[Category: Silman, N J.]]
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[[Category: Tanner, S J.]]
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[[Category: Trincao, J.]]
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[[Category: Wu, W.]]
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[[Category: Viral protein]]

Revision as of 07:01, 22 January 2014

Template:STRUCTURE 4c3e

Contents

HRSV M2-1 mutant S58D S61D, P21 crystal

Function

[M21_HRSVA] Acts as a transcriptional elongation factor to prevent premature termination during transcription thus allowing complete synthesis of RSV mRNAs. Functions also as a processivity and antitermination factor to permit transit of the polymerase through intergenic regions to access promoter distal genes. Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate NF-kappa-B through association with host RELA.[1] [2] [3]

About this Structure

4c3e is a 16 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Collins PL, Hill MG, Cristina J, Grosfeld H. Transcription elongation factor of respiratory syncytial virus, a nonsegmented negative-strand RNA virus. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):81-5. PMID:8552680
  2. ↑ Hardy RW, Wertz GW. The product of the respiratory syncytial virus M2 gene ORF1 enhances readthrough of intergenic junctions during viral transcription. J Virol. 1998 Jan;72(1):520-6. PMID:9420254
  3. ↑ Fearns R, Collins PL. Role of the M2-1 transcription antitermination protein of respiratory syncytial virus in sequential transcription. J Virol. 1999 Jul;73(7):5852-64. PMID:10364337

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