4gg2

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'''Unreleased structure'''
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{{STRUCTURE_4gg2| PDB=4gg2 | SCENE= }}
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===The crystal structure of glutamate-bound human gamma-glutamyltranspeptidase 1===
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The entry 4gg2 is ON HOLD until Sep 30 2014
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==Disease==
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[[http://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN]] Gamma-glutamyl transpeptidase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: West, M.B., Chen, Y., Wickham, S., Heroux, A., Cahill, K., Hanigan, M.H., Mooers, B.H.M.
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==Function==
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[[http://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN]] Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.<ref>PMID:7689219</ref> <ref>PMID:20622017</ref>
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Description: The crystal structure of glutamate-bound human-glutamyltranspeptidase 1
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==About this Structure==
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[[4gg2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Zasmidium_angulare Zasmidium angulare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GG2 OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Zasmidium angulare]]
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[[Category: Cahill, K.]]
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[[Category: Chen, Y.]]
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[[Category: Hanigan, M H.]]
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[[Category: Heroux, A.]]
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[[Category: Mooers, B H.M.]]
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[[Category: West, M B.]]
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[[Category: Wickham, S.]]
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[[Category: Exterior cell surface]]
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[[Category: Glutathionine metabolism]]
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[[Category: Hydrolase]]
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[[Category: N-glycosylation]]
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[[Category: Ntn-hydrolyase]]

Revision as of 08:16, 29 September 2013

Template:STRUCTURE 4gg2

Contents

The crystal structure of glutamate-bound human gamma-glutamyltranspeptidase 1

Disease

[GGT1_HUMAN] Gamma-glutamyl transpeptidase deficiency. The disease is caused by mutations affecting the gene represented in this entry.

Function

[GGT1_HUMAN] Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.[1] [2]

About this Structure

4gg2 is a 2 chain structure with sequence from Homo sapiens and Zasmidium angulare. Full crystallographic information is available from OCA.

Reference

  1. ↑ Wetmore LA, Gerard C, Drazen JM. Human lung expresses unique gamma-glutamyl transpeptidase transcripts. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7461-5. PMID:7689219
  2. ↑ West MB, Segu ZM, Feasley CL, Kang P, Klouckova I, Li C, Novotny MV, West CM, Mechref Y, Hanigan MH. Analysis of site-specific glycosylation of renal and hepatic gamma-glutamyl transpeptidase from normal human tissue. J Biol Chem. 2010 Sep 17;285(38):29511-24. doi: 10.1074/jbc.M110.145938. Epub, 2010 Jul 9. PMID:20622017 doi:10.1074/jbc.M110.145938

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