4ln7

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'''Unreleased structure'''
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{{STRUCTURE_4ln7| PDB=4ln7 | SCENE= }}
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===5,6-bis(4-fluorophenyl)-3-hydroxy-2,5-dihydropyridin-2-one bound to influenza 2009 pH1N1 endonuclease===
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{{ABSTRACT_PUBMED_23978130}}
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The entry 4ln7 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/F0TRT1_9INFA F0TRT1_9INFA]] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication (By similarity).[SAAS:SAAS001009_004_020464]
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Authors: Bauman, J.D., Patel, D., Das, K., Arnold, E.
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==About this Structure==
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[[4ln7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/lima/wrair1695p/2009(h1n1)) Influenza a virus (a/lima/wrair1695p/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LN7 OCA].
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Description: 5,6-bis(4-fluorophenyl)-3-hydroxy-2,5-dihydropyridin-2-one bound to influenza 2009 pH1N1 endonuclease
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==Reference==
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<ref group="xtra">PMID:023978130</ref><references group="xtra"/><references/>
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[[Category: Arnold, E.]]
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[[Category: Bauman, J D.]]
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[[Category: Das, K.]]
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[[Category: Patel, D.]]
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[[Category: Cap-snatching]]
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[[Category: Rna binding protein-inhibitor]]
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[[Category: Rna binding protein-inhibitor complex]]

Revision as of 04:15, 20 September 2013

Template:STRUCTURE 4ln7

Contents

5,6-bis(4-fluorophenyl)-3-hydroxy-2,5-dihydropyridin-2-one bound to influenza 2009 pH1N1 endonuclease

Template:ABSTRACT PUBMED 23978130

Function

[F0TRT1_9INFA] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication (By similarity).[SAAS:SAAS001009_004_020464]

About this Structure

4ln7 is a 1 chain structure with sequence from Influenza a virus (a/lima/wrair1695p/2009(h1n1)). Full crystallographic information is available from OCA.

Reference

  • Bauman JD, Patel D, Baker SF, Vijayan RS, Xiang A, Parhi AK, Martinez-Sobrido L, Lavoie EJ, Das K, Arnold E. Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors. ACS Chem Biol. 2013 Sep 13. PMID:23978130 doi:10.1021/cb400400j

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OCA

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