4m2s

(Difference between revisions)

Revision as of 08:16, 13 November 2013

[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.^[1]

4m2s is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Li J, Jaimes KF, Aller SG. Refined structures of mouse P-Glycoprotein. Protein Sci. 2013 Oct 24. doi: 10.1002/pro.2387. PMID:24155053 doi:http://dx.doi.org/10.1002/pro.2387

↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4m2s|  PDB=4m2s  |  SCENE=  }}
+===Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR===
+{{ABSTRACT_PUBMED_24155053}}
-The entry 4m2s is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>
-Authors: Li, J., Jaimes, K.F., Aller, S.G.
+==About this Structure==
+[[4m2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M2S OCA].
-Description: Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR
+==Reference==
+<ref group="xtra">PMID:024155053</ref><references group="xtra"/><references/>
+[[Category: Mus musculus]]
+[[Category: Xenobiotic-transporting ATPase]]
+[[Category: Aller, S G.]]
+[[Category: Jaimes, K F.]]
+[[Category: Li, J.]]
+[[Category: Adenosine triphosphate]]
+[[Category: Atp-binding cassette transporter]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Multidrug efflux]]