4mfv

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-	'''Unreleased structure'''	+	{{STRUCTURE_4mfv| PDB=4mfv | SCENE= }}
		+	===Crystal structure of human CTNNBL1(residues 33~563)===
-	The entry 4mfv is ON HOLD	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
-	Authors: Ahn, J.W., Kim, S., Kim, K.J.	+	==About this Structure==
		+	[[4mfv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFV OCA].
-	Description: Crystal structure of human CTNNBL1(residues 33~563)	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Ahn, J W.]]
		+	[[Category: Kim, K J.]]
		+	[[Category: Kim, S.]]
		+	[[Category: Arm repeat]]
		+	[[Category: Gene regulation]]

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Revision as of 14:00, 12 March 2014

Template:STRUCTURE 4mfv

Contents 1 Crystal structure of human CTNNBL1(residues 33~563) 2 Function 3 About this Structure 4 Reference

Crystal structure of human CTNNBL1(residues 33~563)

Function

[CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.^{[1] [2]}

About this Structure

4mfv is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

1. ↑ Jabbour L, Welter JF, Kollar J, Hering TM. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics. 2003 Mar;81(3):292-303. PMID:12659813
2. ↑ Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell. 2008 Aug 22;31(4):474-84. doi: 10.1016/j.molcel.2008.07.009. PMID:18722174 doi:10.1016/j.molcel.2008.07.009