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4gh3
From Proteopedia
(Difference between revisions)
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| - | + | ==tRNA Guanine Transglycosylase in complex with phenethyl substituted lin-benzohypoxanthine inhibitor== | |
| - | + | <StructureSection load='4gh3' size='340' side='right' caption='[[4gh3]], [[Resolution|resolution]] 2.06Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4gh3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GH3 FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0EV:4-{2-[(CYCLOHEXYLMETHYL)AMINO]ETHYL}-2-[(2-PHENYLETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0EV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gh1|4gh1]], [[4gg9|4gg9]], [[3sm0|3sm0]], [[3s1g|3s1g]], [[4ghr|4ghr]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tgt, ZMO0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264203 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gh3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gh3 RCSB], [http://www.ebi.ac.uk/pdbsum/4gh3 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | [[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[TRNA-guanine transglycosylase|TRNA-guanine transglycosylase]] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]] | [[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]] | ||
| - | [[Category: Immekus, F | + | [[Category: Immekus, F]] |
| - | [[Category: Klebe, G | + | [[Category: Klebe, G]] |
[[Category: Biosynthesis]] | [[Category: Biosynthesis]] | ||
[[Category: Glycosyltransferase]] | [[Category: Glycosyltransferase]] | ||
Revision as of 18:39, 24 December 2014
tRNA Guanine Transglycosylase in complex with phenethyl substituted lin-benzohypoxanthine inhibitor
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