4jhb

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{{STRUCTURE_4jhb| PDB=4jhb | SCENE= }}
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==Crystal structure of RelB double mutants: Y300F/I335F==
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===Crystal structure of RelB double mutants: Y300F/I335F===
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<StructureSection load='4jhb' size='340' side='right' caption='[[4jhb]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4jhb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JHB FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE]] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jgm|4jgm]], [[1zk9|1zk9]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Relb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jhb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jhb RCSB], [http://www.ebi.ac.uk/pdbsum/4jhb PDBsum]</span></td></tr>
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[[4jhb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JHB OCA].
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</table>
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__TOC__
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==Reference==
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</StructureSection>
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<references group="xtra"/><references/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Ghosh, G.]]
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[[Category: Ghosh, G]]
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[[Category: Huang, D B.]]
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[[Category: Huang, D B]]
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[[Category: Vu, D.]]
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[[Category: Vu, D]]
[[Category: Intertwined dimer]]
[[Category: Intertwined dimer]]
[[Category: Non-canonical side-by side dimer]]
[[Category: Non-canonical side-by side dimer]]
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]

Revision as of 12:45, 21 December 2014

Crystal structure of RelB double mutants: Y300F/I335F

4jhb, resolution 2.44Å

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