2nym

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[[Image:2nym.jpg|left|200px]]<br /><applet load="2nym" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2nym.jpg|left|200px]]
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caption="2nym, resolution 3.600&Aring;" />
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'''Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit'''<br />
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{{Structure
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|PDB= 2nym |SIZE=350|CAPTION= <scene name='initialview01'>2nym</scene>, resolution 3.600&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MN:MANGANESE (II) ION'>MN</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16]
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|GENE= PPP2R1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PPP2R5C, KIAA0044 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PPP2CA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2NYM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MN:'>MN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NYM OCA].
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2NYM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NYM OCA].
==Reference==
==Reference==
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Structure of the protein phosphatase 2A holoenzyme., Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y, Cell. 2006 Dec 15;127(6):1239-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17174897 17174897]
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Structure of the protein phosphatase 2A holoenzyme., Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y, Cell. 2006 Dec 15;127(6):1239-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17174897 17174897]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Phosphoprotein phosphatase]]
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[[Category: Xu, Y.]]
[[Category: Xu, Y.]]
[[Category: MN]]
[[Category: MN]]
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[[Category: heat repeats]]
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[[Category: heat repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:12:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:52:55 2008''

Revision as of 15:52, 20 March 2008

Image:2nym.jpg


PDB ID 2nym

Drag the structure with the mouse to rotate
, resolution 3.600Å
Ligands:
Gene: PPP2R1A (Homo sapiens), PPP2R5C, KIAA0044 (Homo sapiens), PPP2CA (Homo sapiens)
Activity: Phosphoprotein phosphatase, with EC number 3.1.3.16
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit


Overview

Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and a catalytic subunit, and a variable regulatory subunit. Here we report the crystal structure of the heterotrimeric PP2A holoenzyme involving the regulatory subunit B'/B56/PR61. Surprisingly, the B'/PR61 subunit has a HEAT-like (huntingtin-elongation-A subunit-TOR-like) repeat structure, similar to that of the scaffolding subunit. The regulatory B'/B56/PR61 subunit simultaneously interacts with the catalytic subunit as well as the conserved ridge of the scaffolding subunit. The carboxyterminus of the catalytic subunit recognizes a surface groove at the interface between the B'/B56/PR61 subunit and the scaffolding subunit. Compared to the scaffolding subunit in the PP2A core enzyme, formation of the holoenzyme forces the scaffolding subunit to undergo pronounced conformational rearrangements. This structure reveals significant ramifications for understanding the function and regulation of PP2A.

About this Structure

2NYM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the protein phosphatase 2A holoenzyme., Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y, Cell. 2006 Dec 15;127(6):1239-51. PMID:17174897

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