2nz0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2nz0.jpg|left|200px]]<br /><applet load="2nz0" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2nz0.jpg|left|200px]]
-
caption="2nz0, resolution 3.20&Aring;" />
+
 
-
'''Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)'''<br />
+
{{Structure
 +
|PDB= 2nz0 |SIZE=350|CAPTION= <scene name='initialview01'>2nz0</scene>, resolution 3.20&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
 +
|ACTIVITY=
 +
|GENE= KChIP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Kv4.3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
}}
 +
 
 +
'''Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
2NZ0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZ0 OCA].
+
2NZ0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZ0 OCA].
==Reference==
==Reference==
-
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits., Wang H, Yan Y, Liu Q, Huang Y, Shen Y, Chen L, Chen Y, Yang Q, Hao Q, Wang K, Chai J, Nat Neurosci. 2007 Jan;10(1):32-9. Epub 2006 Dec 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17187064 17187064]
+
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits., Wang H, Yan Y, Liu Q, Huang Y, Shen Y, Chen L, Chen Y, Yang Q, Hao Q, Wang K, Chai J, Nat Neurosci. 2007 Jan;10(1):32-9. Epub 2006 Dec 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17187064 17187064]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
Line 23: Line 32:
[[Category: kv4 3]]
[[Category: kv4 3]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:12:41 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:53:00 2008''

Revision as of 15:53, 20 March 2008

Image:2nz0.jpg


PDB ID 2nz0

Drag the structure with the mouse to rotate
, resolution 3.20Å
Ligands: and
Gene: KChIP1 (Homo sapiens), Kv4.3 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)


Overview

KChIPs coassemble with pore-forming Kv4 alpha subunits to form a native complex in the brain and heart and regulate the expression and gating properties of Kv4 K(+) channels, but the mechanisms underlying these processes are unknown. Here we report a co-crystal structure of the complex of human Kv4.3 N-terminus and KChIP1 at a 3.2-A resolution. The structure reveals a unique clamping action of the complex, in which a single KChIP1 molecule, as a monomer, laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner, forming an octamer. The proximal N-terminal peptide of Kv4.3 is sequestered by its binding to an elongated groove on the surface of KChIP1, which is indispensable for the modulation of Kv4.3 by KChIP1, and the same KChIP1 molecule binds to an adjacent T1 domain to stabilize the tetrameric Kv4.3 channels. Taken together with biochemical and functional data, our findings provide a structural basis for the modulation of Kv4 by KChIPs.

About this Structure

2NZ0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits., Wang H, Yan Y, Liu Q, Huang Y, Shen Y, Chen L, Chen Y, Yang Q, Hao Q, Wang K, Chai J, Nat Neurosci. 2007 Jan;10(1):32-9. Epub 2006 Dec 24. PMID:17187064

Page seeded by OCA on Thu Mar 20 17:53:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2nz0"
Personal tools