2lww

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{{STRUCTURE_2lww| PDB=2lww | SCENE= }}
{{STRUCTURE_2lww| PDB=2lww | SCENE= }}
===NMR structure of RelA-TAD/CBP-TAZ1 complex===
===NMR structure of RelA-TAD/CBP-TAZ1 complex===
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{{ABSTRACT_PUBMED_24019758}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024019758</ref><references group="xtra"/><references/>
[[Category: Histone acetyltransferase]]
[[Category: Histone acetyltransferase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]

Revision as of 02:59, 20 September 2013

Template:STRUCTURE 2lww

Contents

NMR structure of RelA-TAD/CBP-TAZ1 complex

Template:ABSTRACT PUBMED 24019758

Function

[CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).[1] [2] [3] [4]

About this Structure

2lww is a 2 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

Reference

  • Mukherjee SP, Behar M, Birnbaum HA, Hoffmann A, Wright PE, Ghosh G. Analysis of the RelA:CBP/p300 Interaction Reveals Its Involvement in NF-kappaB-Driven Transcription. PLoS Biol. 2013 Sep;11(9):e1001647. doi: 10.1371/journal.pbio.1001647. Epub 2013 , Sep 3. PMID:24019758 doi:10.1371/journal.pbio.1001647
  1. ↑ Hung HL, Lau J, Kim AY, Weiss MJ, Blobel GA. CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites. Mol Cell Biol. 1999 May;19(5):3496-505. PMID:10207073
  2. ↑ Xu W, Chen H, Du K, Asahara H, Tini M, Emerson BM, Montminy M, Evans RM. A transcriptional switch mediated by cofactor methylation. Science. 2001 Dec 21;294(5551):2507-11. Epub 2001 Nov 8. PMID:11701890 doi:10.1126/science.1065961
  3. ↑ Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M, Nakajima T, Fukamizu A. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10042-7. Epub 2004 Jun 25. PMID:15220471 doi:10.1073/pnas.0400593101
  4. ↑ Kuo HY, Chang CC, Jeng JC, Hu HM, Lin DY, Maul GG, Kwok RP, Shih HM. SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):16973-8. Epub 2005 Nov 15. PMID:16287980 doi:10.1073/pnas.0504460102

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