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3w97
From Proteopedia
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{{STRUCTURE_3w97| PDB=3w97 | SCENE= }} | {{STRUCTURE_3w97| PDB=3w97 | SCENE= }} | ||
===Crystal Structure of Human Nucleosome Core Particle lacking H2B N-terminal region=== | ===Crystal Structure of Human Nucleosome Core Particle lacking H2B N-terminal region=== | ||
| + | {{ABSTRACT_PUBMED_24251097}} | ||
==Function== | ==Function== | ||
| Line 6: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3w97]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3w97]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W97 OCA]. |
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024251097</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
| - | + | ||
[[Category: Horikoshi, N.]] | [[Category: Horikoshi, N.]] | ||
[[Category: Iwasaki, W.]] | [[Category: Iwasaki, W.]] | ||
Revision as of 08:15, 18 December 2013
Contents |
Crystal Structure of Human Nucleosome Core Particle lacking H2B N-terminal region
Template:ABSTRACT PUBMED 24251097
Function
[H2B1J_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[1] [2] [3] Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.[4] [5] [6]
About this Structure
3w97 is a 10 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Iwasaki W, Miya Y, Horikoshi N, Osakabe A, Taguchi H, Tachiwana H, Shibata T, Kagawa W, Kurumizaka H. Contribution of histone N-terminal tails to the structure and stability of nucleosomes. FEBS Open Bio. 2013 Aug 22;3:363-9. doi: 10.1016/j.fob.2013.08.007. PMID:24251097 doi:http://dx.doi.org/10.1016/j.fob.2013.08.007
- ↑ Kim HS, Cho JH, Park HW, Yoon H, Kim MS, Kim SC. Endotoxin-neutralizing antimicrobial proteins of the human placenta. J Immunol. 2002 Mar 1;168(5):2356-64. PMID:11859126
- ↑ Tollin M, Bergman P, Svenberg T, Jornvall H, Gudmundsson GH, Agerberth B. Antimicrobial peptides in the first line defence of human colon mucosa. Peptides. 2003 Apr;24(4):523-30. PMID:12860195
- ↑ Howell SJ, Wilk D, Yadav SP, Bevins CL. Antimicrobial polypeptides of the human colonic epithelium. Peptides. 2003 Nov;24(11):1763-70. PMID:15019208 doi:10.1016/j.peptides.2003.07.028
- ↑ Kim HS, Cho JH, Park HW, Yoon H, Kim MS, Kim SC. Endotoxin-neutralizing antimicrobial proteins of the human placenta. J Immunol. 2002 Mar 1;168(5):2356-64. PMID:11859126
- ↑ Tollin M, Bergman P, Svenberg T, Jornvall H, Gudmundsson GH, Agerberth B. Antimicrobial peptides in the first line defence of human colon mucosa. Peptides. 2003 Apr;24(4):523-30. PMID:12860195
- ↑ Howell SJ, Wilk D, Yadav SP, Bevins CL. Antimicrobial polypeptides of the human colonic epithelium. Peptides. 2003 Nov;24(11):1763-70. PMID:15019208 doi:10.1016/j.peptides.2003.07.028
