4h5r

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'''Unreleased structure'''
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{{STRUCTURE_4h5r| PDB=4h5r | SCENE= }}
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===HSC70 NBD with Na, Cl and glycerol===
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The entry 4h5r is ON HOLD until Mar 18 2015
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==Function==
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[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref>
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Authors: Stec, B.
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==About this Structure==
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[[4h5r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5R OCA].
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Description: HSC70 NBD with Na, Cl and glycerol
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Stec, B.]]
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[[Category: Hsc70 nbd domain]]
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[[Category: Transcription]]

Revision as of 09:29, 19 March 2014

Template:STRUCTURE 4h5r

Contents

HSC70 NBD with Na, Cl and glycerol

Function

[HSP7C_HUMAN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.[1]

About this Structure

4h5r is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, Isselbacher KJ, Shioda T. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000 Mar 24;275(12):8825-34. PMID:10722728

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