Calcium/Calmodulin-dependent protein kinase
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[[Ca2+/Calmodulin dependent protein kinase]] (CaMK) phosphorylates Ser and Thr. It is regulated by Ca<sup>2+</sup>/[[Calmodulin]] (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. '''CASK''' is a membrane associated CaMK. '''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, ''i.e.'' crystal structure of human native membrane associated Ca<sup>2+</sup>/Calmodulin dependent protein kinase ([[3mfr]]). | [[Ca2+/Calmodulin dependent protein kinase]] (CaMK) phosphorylates Ser and Thr. It is regulated by Ca<sup>2+</sup>/[[Calmodulin]] (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. '''CASK''' is a membrane associated CaMK. '''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, ''i.e.'' crystal structure of human native membrane associated Ca<sup>2+</sup>/Calmodulin dependent protein kinase ([[3mfr]]). | ||
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== 3D Structures of Ca<sup>2+</sup>/Calmodulin dependent protein kinase == | == 3D Structures of Ca<sup>2+</sup>/Calmodulin dependent protein kinase == | ||
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=== CaMKK – CaM kinase kinase === | === CaMKK – CaM kinase kinase === | ||
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[[1iq5]] – CeCaMK CBD+XlCaM – ''Xenopus laevis''<br /> | [[1iq5]] – CeCaMK CBD+XlCaM – ''Xenopus laevis''<br /> | ||
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=== CaMKI – specialized CaM kinase === | === CaMKI – specialized CaM kinase === | ||
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[[1mxe]] – rCaMKI CBD+CaM – rat<br /> | [[1mxe]] – rCaMKI CBD+CaM – rat<br /> | ||
[[1ckk]] – rCaMK CBD chain B+XlCaM<br /> | [[1ckk]] – rCaMK CBD chain B+XlCaM<br /> | ||
[[1a06]] – rCaMK chain A<br /> | [[1a06]] – rCaMK chain A<br /> | ||
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=== CASK – membrane-associated CaMK === | === CASK – membrane-associated CaMK === | ||
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[[3mfr]] – hCASK CBD – human<br /> | [[3mfr]] – hCASK CBD – human<br /> | ||
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[[3c0i]] - hCASK kinase domain+AMP<br /> | [[3c0i]] - hCASK kinase domain+AMP<br /> | ||
[[3mfu]] - hCASK+AMPPNP+Mn<br /> | [[3mfu]] - hCASK+AMPPNP+Mn<br /> | ||
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=== DAPK – death-associated CaMK === | === DAPK – death-associated CaMK === | ||
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[[2x0g]] – hDAPK RD+AD+CaM<br /> | [[2x0g]] – hDAPK RD+AD+CaM<br /> | ||
[[2cke]] – hDAPK+inhibitor<br /> | [[2cke]] – hDAPK+inhibitor<br /> | ||
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=== CaMKII – multifunctional CaM kinase === | === CaMKII – multifunctional CaM kinase === | ||
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[[2vz6]] - hCaMKII α chains A, B+ indirubin-E804<br /> | [[2vz6]] - hCaMKII α chains A, B+ indirubin-E804<br /> | ||
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=== CaMKIV === | === CaMKIV === | ||
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[[2w4o]] – hCaMKIV+inhibitor<br /> | [[2w4o]] – hCaMKIV+inhibitor<br /> | ||
Revision as of 06:34, 17 August 2014
Ca2+/Calmodulin dependent protein kinase (CaMK) phosphorylates Ser and Thr. It is regulated by Ca2+/Calmodulin (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, i.e. crystal structure of human native membrane associated Ca2+/Calmodulin dependent protein kinase (3mfr).
Contents |
3D Structures of Ca2+/Calmodulin dependent protein kinase
Updated on 17-August-2014
CaMKK – CaM kinase kinase
1iq5 – CeCaMK CBD+XlCaM – Xenopus laevis
CaMKI – specialized CaM kinase
1mxe – rCaMKI CBD+CaM – rat
1ckk – rCaMK CBD chain B+XlCaM
1a06 – rCaMK chain A
CASK – membrane-associated CaMK
3mfr – hCASK CBD – human
3mfs – hCASK+AMPPNP
3mft – hCASK+Mn
3c0g – hCASK kinase domain
3c0h - hCASK kinase domain+AMPPNP
3c0i - hCASK kinase domain+AMP
3mfu - hCASK+AMPPNP+Mn
DAPK – death-associated CaMK
2x0g – hDAPK RD+AD+CaM
2cke – hDAPK+inhibitor
CaMKII – multifunctional CaM kinase
2vz6 - hCaMKII α chains A, B+ indirubin-E804
2zv2 – hCaMKII+STO-609
2wel - hCaMKII δ chain D+CaM
2w2c - hCaMKII δ chain ASD
2vn9 - hCaMKII δ chains A-B
3bhh - hCaMKII β chains A-D
2v7o - hCaMKII γ chain A
2ux0 - hCaMKII γ (mutant) chains A-F
2jam - hCaMKI γ+peptides
2jc6 - hCaMKII δ chains A,C
1hkx - mCaMKII α chains A-N ASD - mouse
3gp2 – cCaMKII δ chain B+CaM – chicken
3kk8, 3kk9 – CeCaMKII – Caenorhabditis elegans
3kl8 – CeCaMKII (mutant)+inhibitor
3ksp – CaMKII ASD – Exiguobacterium sibiricum
CaMKIV
2w4o – hCaMKIV+inhibitor
See also
Calcium-dependent protein kinase, a member of the CaM kinase family
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Alice Harmon, Jaime Prilusky
