This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2mbg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{Large structure}}
 +
{{STRUCTURE_2mbg| PDB=2mbg | SCENE= }}
 +
===Rlip76 (gap-gbd)===
 +
{{ABSTRACT_PUBMED_24207123}}
-
The entry 2mbg is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/RBP1_HUMAN RBP1_HUMAN]] Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.<ref>PMID:7673236</ref> <ref>PMID:12775724</ref> <ref>PMID:11437348</ref>
-
Authors: Rajasekar, K.V., Campbell, L.J., Nietlispach, D., Owen, D., Mott, H.R.
+
==About this Structure==
 +
[[2mbg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBG OCA].
-
Description: Rlip76 (gap-gbd)
+
==Reference==
 +
<ref group="xtra">PMID:024207123</ref><references group="xtra"/><references/>
 +
[[Category: Campbell, L J.]]
 +
[[Category: Mott, H R.]]
 +
[[Category: Nietlispach, D.]]
 +
[[Category: Owen, D.]]
 +
[[Category: Rajasekar, K V.]]
 +
[[Category: Protein binding]]
 +
[[Category: Ralbp1]]
 +
[[Category: Rhogap]]

Revision as of 07:24, 4 December 2013

Warning: this is a large structure, and loading might take a long time or not happen at all.

Template:STRUCTURE 2mbg

Contents

Rlip76 (gap-gbd)

Template:ABSTRACT PUBMED 24207123

Function

[RBP1_HUMAN] Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.[1] [2] [3]

About this Structure

2mbg is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Rajasekar KV, Campbell LJ, Nietlispach D, Owen D, Mott HR. The Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the Membrane. Structure. 2013 Oct 22. pii: S0969-2126(13)00357-2. doi:, 10.1016/j.str.2013.09.007. PMID:24207123 doi:http://dx.doi.org/10.1016/j.str.2013.09.007
  1. ↑ Jullien-Flores V, Dorseuil O, Romero F, Letourneur F, Saragosti S, Berger R, Tavitian A, Gacon G, Camonis JH. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J Biol Chem. 1995 Sep 22;270(38):22473-7. PMID:7673236
  2. ↑ Rosse C, L'Hoste S, Offner N, Picard A, Camonis J. RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J Biol Chem. 2003 Aug 15;278(33):30597-604. Epub 2003 May 29. PMID:12775724 doi:http://dx.doi.org/10.1074/jbc.M302191200
  3. ↑ Sharma R, Singhal SS, Cheng J, Yang Y, Sharma A, Zimniak P, Awasthi S, Awasthi YC. RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. Arch Biochem Biophys. 2001 Jul 15;391(2):171-9. PMID:11437348 doi:http://dx.doi.org/10.1006/abbi.2001.2395

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mbg"
Personal tools