4m8n

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'''Unreleased structure'''
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{{STRUCTURE_4m8n| PDB=4m8n | SCENE= }}
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===Crystal Structure of PlexinC1/Rap1B Complex===
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The entry 4m8n is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/RAP1B_HUMAN RAP1B_HUMAN]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.<ref>PMID:20332120</ref> <ref>PMID:18660803</ref>
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Authors: Pascoe, H.G., Wang, Y., Brautigam, C.A., He, H., Zhang, X.
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==About this Structure==
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[[4m8n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8N OCA].
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Description: Crystal Structure of PlexinC1/Rap1B Complex
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Danio rerio]]
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[[Category: Homo sapiens]]
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[[Category: Brautigam, C A.]]
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[[Category: He, H.]]
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[[Category: Pascoe, H G.]]
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[[Category: Wang, Y.]]
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[[Category: Zhang, X.]]
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[[Category: Gtp binding]]
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[[Category: Gtpase]]
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[[Category: Gtpase activating protein]]
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[[Category: Magnesium binding]]
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[[Category: Membrane]]
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[[Category: Rap]]
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[[Category: Signaling protein]]

Revision as of 06:41, 10 October 2013

Template:STRUCTURE 4m8n

Contents

Crystal Structure of PlexinC1/Rap1B Complex

Function

[RAP1B_HUMAN] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.[1] [2]

About this Structure

4m8n is a 8 chain structure with sequence from Danio rerio and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80. doi: 10.1242/jcs.059329. PMID:20332120 doi:10.1242/jcs.059329
  2. ↑ Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature. 2008 Sep 4;455(7209):124-7. Epub 2008 Jul 27. PMID:18660803 doi:http://dx.doi.org/10.1038/nature07187

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