4mjj

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'''Unreleased structure'''
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{{STRUCTURE_4mjj| PDB=4mjj | SCENE= }}
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===Crystal structure of the C2A domain of DOC2A===
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The entry 4mjj is ON HOLD until Oct 28 2014
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==Function==
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[[http://www.uniprot.org/uniprot/DOC2A_HUMAN DOC2A_HUMAN]] Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.<ref>PMID:9736751</ref> <ref>PMID:9804756</ref> <ref>PMID:18354201</ref>
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Authors: Huang, Q.Q.
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==About this Structure==
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[[4mjj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJJ OCA].
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Description: Crystal structure of the C2A domain of DOC2A
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Huang, Q Q.]]
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[[Category: C2 domain]]
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[[Category: Calcium binding protein]]
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[[Category: Doc2a]]
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[[Category: Metal binding protein]]

Revision as of 09:54, 30 October 2013

Template:STRUCTURE 4mjj

Contents

Crystal structure of the C2A domain of DOC2A

Function

[DOC2A_HUMAN] Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.[1] [2] [3]

About this Structure

4mjj is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y. Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11418-22. PMID:9736751
  2. ↑ Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y. Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. J Biol Chem. 1998 Nov 13;273(46):30065-8. PMID:9804756
  3. ↑ Higashio H, Nishimura N, Ishizaki H, Miyoshi J, Orita S, Sakane A, Sasaki T. Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. J Immunol. 2008 Apr 1;180(7):4774-84. PMID:18354201

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