2odr
From Proteopedia
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| - | [[Image:2odr.jpg|left|200px]] | + | [[Image:2odr.jpg|left|200px]] |
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| - | '''Methanococcus Maripaludis Phosphoseryl-tRNA synthetase''' | + | {{Structure |
| + | |PDB= 2odr |SIZE=350|CAPTION= <scene name='initialview01'>2odr</scene>, resolution 3.228Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= MMP0688 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39152 Methanococcus maripaludis]) | ||
| + | }} | ||
| + | |||
| + | '''Methanococcus Maripaludis Phosphoseryl-tRNA synthetase''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2ODR is a [ | + | 2ODR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODR OCA]. |
==Reference== | ==Reference== | ||
| - | Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase., Kamtekar S, Hohn MJ, Park HS, Schnitzbauer M, Sauerwald A, Soll D, Steitz TA, Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2620-5. Epub 2007 Feb 14. PMID:[http:// | + | Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase., Kamtekar S, Hohn MJ, Park HS, Schnitzbauer M, Sauerwald A, Soll D, Steitz TA, Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2620-5. Epub 2007 Feb 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17301225 17301225] |
[[Category: Methanococcus maripaludis]] | [[Category: Methanococcus maripaludis]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: phosphoserine trna synthetase class ii]] | [[Category: phosphoserine trna synthetase class ii]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:58:22 2008'' |
Revision as of 15:58, 20 March 2008
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| , resolution 3.228Å | |||||||
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| Gene: | MMP0688 (Methanococcus maripaludis) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Methanococcus Maripaludis Phosphoseryl-tRNA synthetase
Overview
A number of archaeal organisms generate Cys-tRNA(Cys) in a two-step pathway, first charging phosphoserine (Sep) onto tRNA(Cys) and subsequently converting it to Cys-tRNA(Cys). We have determined, at 3.2-A resolution, the structure of the Methanococcus maripaludis phosphoseryl-tRNA synthetase (SepRS), which catalyzes the first step of this pathway. The structure shows that SepRS is a class II, alpha(4) synthetase whose quaternary structure arrangement of subunits closely resembles that of the heterotetrameric (alphabeta)(2) phenylalanyl-tRNA synthetase (PheRS). Homology modeling of a tRNA complex indicates that, in contrast to PheRS, a single monomer in the SepRS tetramer may recognize both the acceptor terminus and anticodon of a tRNA substrate. Using a complex with tungstate as a marker for the position of the phosphate moiety of Sep, we suggest that SepRS and PheRS bind their respective amino acid substrates in dissimilar orientations by using different residues.
About this Structure
2ODR is a Protein complex structure of sequences from Methanococcus maripaludis. Full crystallographic information is available from OCA.
Reference
Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase., Kamtekar S, Hohn MJ, Park HS, Schnitzbauer M, Sauerwald A, Soll D, Steitz TA, Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2620-5. Epub 2007 Feb 14. PMID:17301225
Page seeded by OCA on Thu Mar 20 17:58:22 2008
