4msv

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m (Protected "4msv" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4msv| PDB=4msv | SCENE= }}
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===Crystal structure of FASL and DcR3 complex===
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The entry 4msv is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Liu, W., Ramagopal, U.A., Zhan, C., Bonanno, J.B., Bhosle, R.C., Nathenson, S.G., Almo, S.C., Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC)
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==Function==
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[[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref> The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref>
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Description: Crystal structure of FASL and DcR3 complex
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==About this Structure==
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[[4msv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSV OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Almo, S C.]]
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[[Category: Bhosle, R C.]]
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[[Category: Bonanno, J B.]]
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[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
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[[Category: Liu, W.]]
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[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
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[[Category: Nathenson, S G.]]
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[[Category: Ramagopal, U A.]]
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[[Category: Zhan, C.]]
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[[Category: Atoms-to-animals: the immune function network]]
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[[Category: Bind tnf receptor fa]]
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[[Category: Cd95l]]
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[[Category: Cytokine]]
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[[Category: Dcr3]]
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[[Category: Fas ligand]]
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[[Category: Fasl]]
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[[Category: Ifn]]
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[[Category: Immune system]]
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[[Category: Immunity]]
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[[Category: Jelly-roll fold]]
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[[Category: Membrane]]
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[[Category: New york structural genomic]]
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[[Category: New york structural genomics research consortium]]
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[[Category: Nysgrc]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Research consortium]]
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[[Category: Secreted protein]]
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[[Category: Structural genomic]]
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[[Category: Tnf]]
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[[Category: Tnf supe cd95l]]
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[[Category: Tnf superfamily]]
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[[Category: Tnf6]]
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[[Category: Tnfr]]

Revision as of 10:35, 27 November 2013

Template:STRUCTURE 4msv

Contents

Crystal structure of FASL and DcR3 complex

Disease

[TNFL6_HUMAN] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

[TNF6B_HUMAN] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.[1] [TNFL6_HUMAN] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.[2] The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.[3]

About this Structure

4msv is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC. Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure. 2011 Feb 9;19(2):162-71. PMID:21300286 doi:10.1016/j.str.2010.12.004
  2. ↑ Kirkin V, Cahuzac N, Guardiola-Serrano F, Huault S, Luckerath K, Friedmann E, Novac N, Wels WS, Martoglio B, Hueber AO, Zornig M. The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. Cell Death Differ. 2007 Sep;14(9):1678-87. Epub 2007 Jun 8. PMID:17557115 doi:http://dx.doi.org/10.1038/sj.cdd.4402175
  3. ↑ Kirkin V, Cahuzac N, Guardiola-Serrano F, Huault S, Luckerath K, Friedmann E, Novac N, Wels WS, Martoglio B, Hueber AO, Zornig M. The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. Cell Death Differ. 2007 Sep;14(9):1678-87. Epub 2007 Jun 8. PMID:17557115 doi:http://dx.doi.org/10.1038/sj.cdd.4402175

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