4c0a
From Proteopedia
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{{STRUCTURE_4c0a| PDB=4c0a | SCENE= }} | {{STRUCTURE_4c0a| PDB=4c0a | SCENE= }} | ||
===Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain=== | ===Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain=== | ||
| + | {{ABSTRACT_PUBMED_24058294}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4c0a]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0A OCA]. | [[4c0a]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0A OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024058294</ref><references group="xtra"/><references/> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 06:22, 2 October 2013
Contents |
Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain
Template:ABSTRACT PUBMED 24058294
Function
[ARF1_BOVIN] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
About this Structure
4c0a is a 8 chain structure with sequence from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Aizel K, Biou V, Navaza J, Duarte LV, Campanacci V, Cherfils J, Zeghouf M. Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2. PLoS Biol. 2013 Sep;11(9):e1001652. doi: 10.1371/journal.pbio.1001652. Epub 2013 , Sep 10. PMID:24058294 doi:10.1371/journal.pbio.1001652
