4h8i

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{{STRUCTURE_4h8i| PDB=4h8i | SCENE= }}
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==Structure of GluK2-LBD in complex with GluAzo==
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===Structure of GluK2-LBD in complex with GluAzo===
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<StructureSection load='4h8i' size='340' side='right' caption='[[4h8i]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4h8i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H8I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=11W:(4R)-4-[(2E)-3-{4-[(E)-PHENYLDIAZENYL]PHENYL}PROP-2-EN-1-YL]-L-GLUTAMIC+ACID'>11W</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h8j|4h8j]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Glur6, Grik2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h8i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h8i RCSB], [http://www.ebi.ac.uk/pdbsum/4h8i PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
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*[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4h8i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H8I OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Reiter, A.]]
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[[Category: Reiter, A]]
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[[Category: Schiefner, A.]]
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[[Category: Schiefner, A]]
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[[Category: Skerra, A.]]
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[[Category: Skerra, A]]
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[[Category: Trauner, D.]]
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[[Category: Trauner, D]]
[[Category: Gluazo]]
[[Category: Gluazo]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]

Revision as of 11:50, 21 December 2014

Structure of GluK2-LBD in complex with GluAzo

4h8i, resolution 2.00Å

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