4itc
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4itc| PDB=4itc | SCENE= }} | {{STRUCTURE_4itc| PDB=4itc | SCENE= }} | ||
===Crystal Structure Analysis of the K1 Cleaved Adhesin domain of Lys-gingipain (Kgp) from Porphyromonas gingivalis W83=== | ===Crystal Structure Analysis of the K1 Cleaved Adhesin domain of Lys-gingipain (Kgp) from Porphyromonas gingivalis W83=== | ||
| + | {{ABSTRACT_PUBMED_24265933}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4itc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4itc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33277 Atcc 33277]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ITC OCA]. |
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024265933</ref><references group="xtra"/><references/> | ||
| + | [[Category: Atcc 33277]] | ||
[[Category: Gingipain K]] | [[Category: Gingipain K]] | ||
| - | [[Category: Porphyromonas gingivalis]] | ||
[[Category: Collyer, C A.]] | [[Category: Collyer, C A.]] | ||
[[Category: Ganuelas, L A.]] | [[Category: Ganuelas, L A.]] | ||
Revision as of 06:38, 15 January 2014
Contents |
Crystal Structure Analysis of the K1 Cleaved Adhesin domain of Lys-gingipain (Kgp) from Porphyromonas gingivalis W83
Template:ABSTRACT PUBMED 24265933
Function
[KGP83_PORGN] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]
About this Structure
4itc is a 1 chain structure with sequence from Atcc 33277. Full crystallographic information is available from OCA.
Reference
- Ganuelas LA, Li N, Yun P, Hunter N, Collyer CA. The lysine gingipain adhesin domains from Porphyromonas gingivalis interact with erythrocytes and albumin: Structures correlate to function. Eur J Microbiol Immunol (Bp). 2013 Sep;3(3):152-62. doi:, 10.1556/EuJMI.3.2013.3.2. Epub 2013 Sep 23. PMID:24265933 doi:http://dx.doi.org/10.1556/EuJMI.3.2013.3.2
