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4mep

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{{STRUCTURE_4mep| PDB=4mep | SCENE= }}
{{STRUCTURE_4mep| PDB=4mep | SCENE= }}
===Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand===
===Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand===
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{{ABSTRACT_PUBMED_24090311}}
==Disease==
==Disease==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024090311</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H.]]

Revision as of 08:32, 30 October 2013

Template:STRUCTURE 4mep

Contents

Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand

Template:ABSTRACT PUBMED 24090311

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4mep is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Vidler LR, Filippakopoulos P, Fedorov O, Picaud S, Martin S, Tomsett M, Woodward H, Brown N, Knapp S, Hoelder S. Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening. J Med Chem. 2013 Oct 3. PMID:24090311 doi:http://dx.doi.org/10.1021/jm4011302
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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