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4gv5
From Proteopedia
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{{STRUCTURE_4gv5| PDB=4gv5 | SCENE= }} | {{STRUCTURE_4gv5| PDB=4gv5 | SCENE= }} | ||
===X-ray structure of crotamine, a cell-penetrating peptide from the Brazilian snake Crotalus durissus terrificus=== | ===X-ray structure of crotamine, a cell-penetrating peptide from the Brazilian snake Crotalus durissus terrificus=== | ||
| + | {{ABSTRACT_PUBMED_24100315}} | ||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024100315</ref><references group="xtra"/><references/> |
[[Category: Crotalus durissus terrificus]] | [[Category: Crotalus durissus terrificus]] | ||
[[Category: Arni, R K.]] | [[Category: Arni, R K.]] | ||
Revision as of 05:08, 23 October 2013
Contents |
X-ray structure of crotamine, a cell-penetrating peptide from the Brazilian snake Crotalus durissus terrificus
Template:ABSTRACT PUBMED 24100315
Function
[MYXC_CRODU] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.[1] [2]
About this Structure
4gv5 is a 3 chain structure with sequence from Crotalus durissus terrificus. Full crystallographic information is available from OCA.
Reference
- Coronado MA, Gabdulkhakov A, Georgieva D, Sankaran B, Murakami MT, Arni RK, Betzel C. Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus. Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):1958-64. doi:, 10.1107/S0907444913018003. Epub 2013 Sep 20. PMID:24100315 doi:http://dx.doi.org/10.1107/S0907444913018003
- ↑ Laure CJ. [The primary structure of crotamine (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-5. PMID:1176086
- ↑ Mancin AC, Soares AM, Andriao-Escarso SH, Faca VM, Greene LJ, Zuccolotto S, Pela IR, Giglio JR. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. 1998 Dec;36(12):1927-37. PMID:9839677
