4jiy
From Proteopedia
(Difference between revisions)
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| - | + | ==RNA three-way junction stabilized by a supramolecular di-iron(II) cylinder drug== | |
| - | + | <StructureSection load='4jiy' size='340' side='right' caption='[[4jiy]], [[Resolution|resolution]] 1.91Å' scene=''> | |
| - | { | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[4jiy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JIY FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=NPM:N-[(1E)-PYRIDIN-2-YLMETHYLENE]-N-[4-(4-{[(1E)-PYRIDIN-2-YLMETHYLENE]AMINO}BENZYL)PHENYL]AMINE'>NPM</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2et0|2et0]], [[3fx8|3fx8]], [[3i1d|3i1d]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jiy RCSB], [http://www.ebi.ac.uk/pdbsum/4jiy PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Getting to the heart of it: Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in pi-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder. | ||
| - | + | Binding of a Designed Anti-cancer Drug to the Central Cavity of an RNA Three-Way Junction.,Phongtongpasuk S, Paulus S, Schnabl J, Sigel RK, Spingler B, Hannon MJ, Freisinger E Angew Chem Int Ed Engl. 2013 Aug 23. doi: 10.1002/anie.201305079. PMID:24039102<ref>PMID:24039102</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Freisinger, E | + | == References == |
| - | [[Category: Hannon, M J | + | <references/> |
| - | [[Category: Schnabl, J A | + | __TOC__ |
| - | [[Category: Sigel, R K.O | + | </StructureSection> |
| - | [[Category: Spingler, B | + | [[Category: Freisinger, E]] |
| + | [[Category: Hannon, M J]] | ||
| + | [[Category: Schnabl, J A]] | ||
| + | [[Category: Sigel, R K.O]] | ||
| + | [[Category: Spingler, B]] | ||
[[Category: Cylinder]] | [[Category: Cylinder]] | ||
[[Category: Drug-rna complex]] | [[Category: Drug-rna complex]] | ||
Revision as of 15:29, 21 December 2014
RNA three-way junction stabilized by a supramolecular di-iron(II) cylinder drug
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