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4c74

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'''Unreleased structure'''
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{{STRUCTURE_4c74| PDB=4c74 | SCENE= }}
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===Phenylacetone monooxygenase: Reduced enzyme in complex with APADP===
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{{ABSTRACT_PUBMED_24443704}}
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The entry 4c74 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PAMO_THEFY PAMO_THEFY]] Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl acetate. Can also oxidize other aromatic ketones (benzylacetone, alpha-methylphenylacetone and 4-hydroxyacetophenone), some aliphatic ketones (dodecan-2-one and bicyclohept-2-en-6-one) and sulfides (e.g. methyl 4-tolylsulfide).
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Authors: Martinoli, C., Fraaije, M.W., Mattevi, A.
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==About this Structure==
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[[4c74]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C74 OCA].
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Description: Phenylacetone monooxygenase: Reduced enzyme in complex with APADP
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==Reference==
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<ref group="xtra">PMID:024443704</ref><references group="xtra"/><references/>
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[[Category: Phenylacetone monooxygenase]]
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[[Category: Fraaije, M W.]]
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[[Category: Martinoli, C.]]
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[[Category: Mattevi, A.]]
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[[Category: Baeyer-villiger]]
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[[Category: Cofactor]]
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[[Category: Flavin]]
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[[Category: Oxidoreductase]]

Revision as of 11:16, 5 February 2014

Template:STRUCTURE 4c74

Contents

Phenylacetone monooxygenase: Reduced enzyme in complex with APADP

Template:ABSTRACT PUBMED 24443704

Function

[PAMO_THEFY] Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl acetate. Can also oxidize other aromatic ketones (benzylacetone, alpha-methylphenylacetone and 4-hydroxyacetophenone), some aliphatic ketones (dodecan-2-one and bicyclohept-2-en-6-one) and sulfides (e.g. methyl 4-tolylsulfide).

About this Structure

4c74 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Martinoli C, Dudek HM, Orru R, Edmondson DE, Fraaije MW, Mattevi A. Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction. ACS Catal. 2013;3(12):3058-3062. PMID:24443704 doi:http://dx.doi.org/10.1021/cs400837z

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OCA

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