4c7n

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m (Protected "4c7n" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4c7n| PDB=4c7n | SCENE= }}
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===Crystal Structure of the synthetic peptide iM10 in complex with the coiled-coil region of MITF===
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{{ABSTRACT_PUBMED_24631970}}
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The entry 4c7n is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/MITF_HUMAN MITF_HUMAN]] MITF-related melanoma and renal cell carcinoma predisposition syndrome;Clear cell renal carcinoma;Papillary renal cell carcinoma;Tietz syndrome;Waardenburg syndrome type 2;Ocular albinism with congenital sensorineural deafness. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Authors: Wohlwend, D., Gerhardt, S., Kuekenshoener, T., Einsle, O.
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==Function==
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[[http://www.uniprot.org/uniprot/MITF_HUMAN MITF_HUMAN]] Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.<ref>PMID:10587587</ref> <ref>PMID:22647378</ref>
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Description: Crystal Structure of the synthetic peptide iM10 in complex with the coiled-coil region of MITF
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==About this Structure==
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[[4c7n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7N OCA].
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==Reference==
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<ref group="xtra">PMID:024631970</ref><references group="xtra"/><references/>
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[[Category: Einsle, O.]]
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[[Category: Gerhardt, S.]]
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[[Category: Kuekenshoener, T.]]
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[[Category: Wohlwend, D.]]
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[[Category: Coiled-coil]]
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[[Category: Protein engineering]]
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[[Category: Transcription]]

Revision as of 09:16, 2 April 2014

Template:STRUCTURE 4c7n

Contents

Crystal Structure of the synthetic peptide iM10 in complex with the coiled-coil region of MITF

Template:ABSTRACT PUBMED 24631970

Disease

[MITF_HUMAN] MITF-related melanoma and renal cell carcinoma predisposition syndrome;Clear cell renal carcinoma;Papillary renal cell carcinoma;Tietz syndrome;Waardenburg syndrome type 2;Ocular albinism with congenital sensorineural deafness. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

[MITF_HUMAN] Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.[1] [2]

About this Structure

4c7n is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kukenshoner T, Wohlwend D, Niemoller C, Dondapati P, Speck J, Adeniran AV, Nieth A, Gerhardt S, Einsle O, Muller KM, Arndt KM. Improving coiled coil stability while maintaining specificity by a bacterial hitchhiker selection system. J Struct Biol. 2014 Mar 12. pii: S1047-8477(14)00053-7. doi:, 10.1016/j.jsb.2014.03.002. PMID:24631970 doi:http://dx.doi.org/10.1016/j.jsb.2014.03.002
  1. ↑ Takeda K, Takemoto C, Kobayashi I, Watanabe A, Nobukuni Y, Fisher DE, Tachibana M. Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance. Hum Mol Genet. 2000 Jan 1;9(1):125-32. PMID:10587587
  2. ↑ Genovese G, Ghosh P, Li H, Rettino A, Sioletic S, Cittadini A, Sgambato A. The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells. Cell Cycle. 2012 Jun 1;11(11):2206-15. doi: 10.4161/cc.20765. Epub 2012 Jun 1. PMID:22647378 doi:http://dx.doi.org/10.4161/cc.20765

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