4m6r

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'''Unreleased structure'''
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{{STRUCTURE_4m6r| PDB=4m6r | SCENE= }}
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===Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme===
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{{ABSTRACT_PUBMED_24367089}}
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The entry 4m6r is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MTNB_HUMAN MTNB_HUMAN]] Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.<ref>PMID:15262985</ref> <ref>PMID:23285211</ref> <ref>PMID:22837397</ref>
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Authors: Kang, W., Hong, S.H., Lee, H.M., Kim, N.Y., Lim, Y.C., Le, L.T.M., Kim, H.C., Kim, T.Y., Ashida, H., Yokota, A., Hah, S.S., Chun, K.H., Jung, Y.-K., Yang, J.K.
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==About this Structure==
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[[4m6r]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6R OCA].
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Description: Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme
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==Reference==
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<ref group="xtra">PMID:024367089</ref><references group="xtra"/><references/>
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[[Category: Methylthioribulose 1-phosphate dehydratase]]
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[[Category: Ashida, H.]]
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[[Category: Chun, K H.]]
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[[Category: Hah, S S.]]
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[[Category: Hong, S H.]]
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[[Category: Jung, Y K.]]
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[[Category: Kang, W.]]
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[[Category: Kim, H C.]]
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[[Category: Kim, N Y.]]
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[[Category: Kim, T Y.]]
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[[Category: Le, L T.M.]]
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[[Category: Lee, H M.]]
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[[Category: Lim, B.]]
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[[Category: Lim, Y C.]]
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[[Category: Yang, J K.]]
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[[Category: Yokota, A.]]
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[[Category: Apip]]
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[[Category: Class ii aldolase family]]
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[[Category: Dehydratase]]
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[[Category: Lyase]]
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[[Category: Mtnb]]

Revision as of 07:41, 29 January 2014

Template:STRUCTURE 4m6r

Contents

Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme

Template:ABSTRACT PUBMED 24367089

Function

[MTNB_HUMAN] Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.[1] [2] [3]

About this Structure

4m6r is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kang W, Hong SH, Lee HM, Kim NY, Lim YC, Le le TM, Lim B, Kim HC, Kim TY, Ashida H, Yokota A, Hah SS, Chun KH, Jung YK, Yang JK. Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E54-61. doi: 10.1073/pnas.1308768111., Epub 2013 Dec 23. PMID:24367089 doi:http://dx.doi.org/10.1073/pnas.1308768111
  1. ↑ Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK. Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein. J Biol Chem. 2004 Sep 17;279(38):39942-50. Epub 2004 Jul 15. PMID:15262985 doi:http://dx.doi.org/10.1074/jbc.M405747200
  2. ↑ Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L. Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway. PLoS One. 2012;7(12):e52877. doi: 10.1371/journal.pone.0052877. Epub 2012 Dec 28. PMID:23285211 doi:http://dx.doi.org/10.1371/journal.pone.0052877
  3. ↑ Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2343-52. doi:, 10.1073/pnas.1206701109. Epub 2012 Jul 25. PMID:22837397 doi:http://dx.doi.org/10.1073/pnas.1206701109

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